1-Pentanol, 2-fluoro-5,5-bis(phenylmethoxy)-

Base Information

Chemical Name:1-Pentanol, 2-fluoro-5,5-bis(phenylmethoxy)-
CAS No.:645413-07-6
Molecular Formula:C19H23FO3
Molecular Weight:318.388
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Pentanol, 2-fluoro-5,5-bis(phenylmethoxy)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Pentanol, 2-fluoro-5,5-bis(phenylmethoxy)-

There total 6 articles about 1-Pentanol, 2-fluoro-5,5-bis(phenylmethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 645413-06-5
5-(tert-butyldiphenylsilyloxy)-4-fluoropentanaldibenzylacetal

: 645413-07-6
4-fluoro-1,1-dibenzyloxy-5-pentanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 23h;
DOI:10.1021/ja037935a

Reference yield:

: 3885-22-1
ethyl-2-fluoro-4-pentenoate

: 645413-07-6
4-fluoro-1,1-dibenzyloxy-5-pentanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: LiAlH₄ / diethyl ether / 18 h / 23 °C

2.1: 13.17 g / imidazole / dimethylformamide / 12 h

3.1: BH₃*SMe₂ / tetrahydrofuran / 72 h / 23 °C

3.2: 83 percent / aq. H₂O₂; NaOH / tetrahydrofuran / 48 h / 23 °C

4.1: 95 percent / Dess-Martin periodinane / CH₂Cl₂ / 16 h

5.1: 86 percent / p-toluenesulfonic acid monohydrate / benzene / 20 h / 80 °C

6.1: 86 percent / tetrabutylammonium fluoride / tetrahydrofuran / 23 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; Dess-Martin periodane; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; benzene; 4.1: Dess-Martin oxidation;
DOI:10.1021/ja037935a

Reference yield:

: 2-fluoro-4-penten-1-ol

: 645413-07-6
4-fluoro-1,1-dibenzyloxy-5-pentanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 13.17 g / imidazole / dimethylformamide / 12 h

2.1: BH₃*SMe₂ / tetrahydrofuran / 72 h / 23 °C

2.2: 83 percent / aq. H₂O₂; NaOH / tetrahydrofuran / 48 h / 23 °C

3.1: 95 percent / Dess-Martin periodinane / CH₂Cl₂ / 16 h

4.1: 86 percent / p-toluenesulfonic acid monohydrate / benzene / 20 h / 80 °C

5.1: 86 percent / tetrabutylammonium fluoride / tetrahydrofuran / 23 h / 20 °C

With 1H-imidazole; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; Dess-Martin periodane; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene; 3.1: Dess-Martin oxidation;
DOI:10.1021/ja037935a