Calpain Inhibitor VI

Base Information

Chemical Name:Calpain Inhibitor VI
CAS No.:190274-53-4
Molecular Formula:C17H25FN2O4S
Molecular Weight:372.461
Hs Code.:
Nikkaji Number:J898.242B
Pharos Ligand ID:QHNU2WAM434H
ChEMBL ID:CHEMBL288365
Mol file:190274-53-4.mol

Synonyms:N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal;SJA 6017;SJA-6017;SJA6017

Suppliers and Price of Calpain Inhibitor VI

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Cayman Chemical
Calpain Inhibitor VI ≥95%
1mg
$ 59.00

Biosynth Carbosynth
Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde
500 ug
$ 135.00

Biosynth Carbosynth
Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde
1 mg
$ 236.00

Biosynth Carbosynth
Calpain Inhibitor VI 4-Fluoro-benzenesulfonyl-Val-Leu-aldehyde
10 mg
$ 1429.60

American Custom Chemicals Corporation
SJA6017 95.00%
5MG
$ 1303.53

American Custom Chemicals Corporation
SJA6017 95.00%
1MG
$ 722.80

AK Scientific
CalpainInhibitorVI
1mg
$ 179.00

Total 13 raw suppliers

Chemical Property of Calpain Inhibitor VI

Chemical Property:

PSA：100.72000
LogP:3.72100
XLogP3:3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:9
Exact Mass:372.15190662
Heavy Atom Count:25
Complexity:537

Purity/Quality:

98%Min ^*data from raw suppliers

Calpain Inhibitor VI ≥95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CC(C=O)NC(=O)C(C(C)C)NS(=O)(=O)C1=CC=C(C=C1)F
Isomeric SMILES:CC(C)C[C@@H](C=O)NC(=O)[C@H](C(C)C)NS(=O)(=O)C1=CC=C(C=C1)F
Description Calpain inhibitor VI is an inhibitor of the calcium-dependent cysteine proteases μ-calpain (calpain-1; IC50 = 7.5 nM) and m-calpain (calpain-2; IC50 = 78 nM). It also inhibits cathepsins B and L (IC50s = 15 and 1.6 nM, respectively). It is selective for these calpains and cathepsins over other cysteine and serine proteases, factor VIIa, factor Xa, trypsin, chymotrypsin, and proteasome. In an in vitro porcine model of cataract, calpain inhibitor VI decreases the degree of cataract by 40% when used at a concentration of 0.8 μM. It also prevents cataract formation induced by selenite in rats when administered at a dose of 100 mg/kg for 4 days. Calpain inhibitor VI improves functional outcome and reduces apoptotic cell death in a rat model of spinal cord injury.

Technology Process of Calpain Inhibitor VI

There total 9 articles about Calpain Inhibitor VI which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 797049-70-8
methyl (2'S,2S)-2-[2-(4-fluorobenzenesulfonylamino)-3-methylbutanoylamino]-4-methylpentanoate

: 190274-53-4
N-((4-Fluorophenyl)sulfonyl)-L-valyl-L-leucinal

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; at -78 ℃; for 3h;
DOI:10.1071/CH04080

Reference yield: 60.0%

: 438003-82-8
(2S)-2-((4-fluorophenyl)sulfonylamino)-N-((1S)-1-(hydroxymethyl)-3-methylbutyl)-3-methylbutanamide

: 190274-53-4
N-((4-Fluorophenyl)sulfonyl)-L-valyl-L-leucinal

Guidance literature:: With sulfur trioxide pyridine complex; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide; at 20 ℃; for 0.666667h;

Reference yield:

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: 190274-53-4
N-((4-Fluorophenyl)sulfonyl)-L-valyl-L-leucinal

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / iPr₂NEt / CH₂Cl₂ / 4 h / Heating

2: 97 percent / KOH / H₂O; tetrahydrofuran / 3 h / 40 °C

3: 89 percent / BOP; iPr₂NEt / CH₂Cl₂ / 24 h

4: 73 percent / DIBALH / CH₂Cl₂ / 3 h / -78 °C

With potassium hydroxide; diisobutylaluminium hydride; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1071/CH04080