methyl (2'S,2S)-2-[2-(4-fluorobenzenesulfonylamino)-3-methylbutanoylamino]-4-methylpentanoate

Base Information

Chemical Name:methyl (2'S,2S)-2-[2-(4-fluorobenzenesulfonylamino)-3-methylbutanoylamino]-4-methylpentanoate
CAS No.:797049-70-8
Molecular Formula:C₁₈H₂₇FN₂O₅S
Molecular Weight:402.487
Hs Code.:

Synonyms:methyl (2'S,2S)-2-[2-(4-fluorobenzenesulfonylamino)-3-methylbutanoylamino]-4-methylpentanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl (2'S,2S)-2-[2-(4-fluorobenzenesulfonylamino)-3-methylbutanoylamino]-4-methylpentanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of methyl (2'S,2S)-2-[2-(4-fluorobenzenesulfonylamino)-3-methylbutanoylamino]-4-methylpentanoate

There total 4 articles about methyl (2'S,2S)-2-[2-(4-fluorobenzenesulfonylamino)-3-methylbutanoylamino]-4-methylpentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 2666-93-5
(S)-Leu-OMe

: 97801-48-4
(S)-2-(4-fluorobenzenesulfonylamino)-3-methylbutanoic acid

: 797049-70-8
methyl (2'S,2S)-2-[2-(4-fluorobenzenesulfonylamino)-3-methylbutanoylamino]-4-methylpentanoate

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; for 24h;
DOI:10.1071/CH04080

Reference yield:

: 797049-66-2
methyl (S)-2-(4-fluorobenzenesulfonylamino)-3-methylbutanoate

: 797049-70-8
methyl (2'S,2S)-2-[2-(4-fluorobenzenesulfonylamino)-3-methylbutanoylamino]-4-methylpentanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / KOH / H₂O; tetrahydrofuran / 3 h / 40 °C

2: 89 percent / BOP; iPr₂NEt / CH₂Cl₂ / 24 h

With potassium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1071/CH04080

Reference yield:

: 4070-48-8
L-Valine methyl ester

: 797049-70-8
methyl (2'S,2S)-2-[2-(4-fluorobenzenesulfonylamino)-3-methylbutanoylamino]-4-methylpentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / iPr₂NEt / CH₂Cl₂ / 4 h / Heating

2: 97 percent / KOH / H₂O; tetrahydrofuran / 3 h / 40 °C

3: 89 percent / BOP; iPr₂NEt / CH₂Cl₂ / 24 h

With potassium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1071/CH04080