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Lithium diisopropylamide

Base Information Edit
  • Chemical Name:Lithium diisopropylamide
  • CAS No.:4111-54-0
  • Deprecated CAS:26396-97-4,34440-82-9,75792-99-3,81236-19-3,1201899-45-7,1201899-48-0,1514924-08-3,1201899-48-0,34440-82-9,75792-99-3,81236-19-3
  • Molecular Formula:C6H15 N . Li
  • Molecular Weight:107.125
  • Hs Code.:29211990
  • European Community (EC) Number:223-893-0
  • UNII:OL028KIW1I
  • DSSTox Substance ID:DTXSID6063305
  • Nikkaji Number:J224.914F
  • Wikipedia:Lithium_diisopropylamide
  • Wikidata:Q413164
  • Mol file:4111-54-0.mol
Lithium diisopropylamide

Synonyms:diisopropylamine;diisopropylamine hydrochloride;diisopropylamine sulfate (2:1);diisopropylamine, lithium salt;Disotat;lithium diisopropylamide;N,N-diisopropylamine

Suppliers and Price of Lithium diisopropylamide
Supply Marketing:Edit
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • Usbiological
  • Lithium diisopropylamide
  • 50g
  • $ 446.00
  • TCI Chemical
  • Lithium Diisopropylamide (ca. 20% in Tetrahydrofuran/Ethylbenzene/Heptane, ca. 1.5mol/L)
  • 500mL
  • $ 167.00
  • TCI Chemical
  • Lithium Diisopropylamide (ca. 20% in Tetrahydrofuran/Ethylbenzene/Heptane, ca. 1.5mol/L)
  • 100mL
  • $ 60.00
  • Sigma-Aldrich
  • Lithium diisopropylamide 97%
  • 25g
  • $ 219.00
  • Sigma-Aldrich
  • Lithium diisopropylamide solution 2.0 M in THF/heptane/ethylbenzene
  • 800ml
  • $ 209.00
  • Sigma-Aldrich
  • Lithium diisopropylamide solution 2.0 M in THF/heptane/ethylbenzene
  • 4x100ml
  • $ 198.00
  • Sigma-Aldrich
  • Lithium diisopropylamide solution 2.0 M in THF/heptane/ethylbenzene
  • 100ml
  • $ 57.30
  • Sigma-Aldrich
  • Lithium diisopropylamide solution 1.0 M in THF/hexanes
  • 100ml
  • $ 54.10
  • Sigma-Aldrich
  • Lithium diisopropylamide solution 1.0 M in THF/hexanes
  • 500ml
  • $ 161.00
  • Sigma-Aldrich
  • Lithium diisopropylamide solution 2.0 M in THF/heptane/ethylbenzene
  • 4x25ml
  • $ 103.00
Total 140 raw suppliers
Chemical Property of Lithium diisopropylamide Edit
Chemical Property:
  • Appearance/Colour:dark yellow to orange or dark red-brown solution 
  • Melting Point:38-42ºC 
  • Boiling Point:83.9 °C at 760 mmHg 
  • Flash Point:-18 ºC 
  • PSA:3.24000 
  • Density:0.79 
  • LogP:1.56950 
  • Storage Temp.:2-8°C 
  • Sensitive.:Air & Moisture Sensitive 
  • Water Solubility.:decomposes 
  • Hydrogen Bond Donor Count:0
  • Hydrogen Bond Acceptor Count:1
  • Rotatable Bond Count:2
  • Exact Mass:107.12862789
  • Heavy Atom Count:8
  • Complexity:37.8
Purity/Quality:

99% *data from raw suppliers

Lithium diisopropylamide *data from reagent suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes:C,N,F 
  • Statements: 14-17-34-67-65-51/53-35-19-15-11-50/53-14/15-10-40-23/24/25-62-63-37-48/20 
  • Safety Statements: 26-36/37/39-43-45-60-61-62-8-16-23-33-27 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Chemical Classes:Metals -> Organic Compounds, Metal Salts
  • Canonical SMILES:[Li+].CC(C)[N-]C(C)C
  • Uses Lithium diisopropylamide is a sterically hindered nonnucleophilic strong base used for selective deprotonations, especially for the production of kinetic enolates (i.e., the thermodynamically less favored isomer) and (hetero-)aromatic carbanions. In the production of the serum lipid regulating agent Gemfibrozil one key intermediate is formed by quenching an ester enolate with 1-bromo-3-chloropropane. pH adjuster in colognes and toilet waters. In organic synthesis, particularly, the lithium salt. Lithium diisopropylamide solution (LDA) can be used:As an initiator in the anionic polymerization of D,L-lactide and methyl methacrylate.To facilitate ester enolization.To convert carboxylic acids to enediolate intermediates for preparing trifluoromethyl ketones.In ortho-lithiation of arylsulfonyloxazolidinones to prepare N-substituted saccharin analogs.To catalyze ortholithiation and Fries rearrangement of aryl carbamates.As a promoter in the isomerization of allylic ethers to (Z)-propenyl ethers.
Technology Process of Lithium diisopropylamide

There total 116 articles about Lithium diisopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:
Guidance literature:
With n-butyllithium; In tetrahydrofuran; at -78 - -65 ℃;
Guidance literature:
With tetramethylsilane; In tetrahydrofuran; hexane; at -73 ℃; for 0.0333333h;
DOI:10.1021/jo00246a052
Refernces Edit
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