N-Methyl-N-(4-Methylphenyl)aMinoacetonitrile

Base Information

• Chemical Name: N-Methyl-N-(4-Methylphenyl)aMinoacetonitrile
• CAS No.: 64672-68-0
• Molecular Formula: C10H12N2
• Molecular Weight: 160.219
• Mol file: 64672-68-0.mol

Synonyms:

Chemical Property of N-Methyl-N-(4-Methylphenyl)aMinoacetonitrile

Chemical Property:

• Boiling Point: 156-157℃ (9 Torr)
• PKA: 2.21±0.50(Predicted)
• Density: 1.043±0.06 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-Methyl-N-(4-Methylphenyl)aMinoacetonitrile

There total 26 articles about N-Methyl-N-(4-Methylphenyl)aMinoacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

sodium cyanide (773837-37-9) + Dimethyl-p-toluidine (99-97-8) → 2-[methyl(p-tolyl)amino]acetonitrile (64672-68-0)

Guidance literature:

With C₄₇H₄₅Cl₂N₅Ru₂⁽²⁺⁾*2F₆P^(1-); dihydrogen peroxide; acetic acid; In methanol; at 60 ℃; for 10h; Inert atmosphere;

DOI:10.1002/jccs.201300084

Reference yield: 97.0%

Dimethyl-p-toluidine (99-97-8) → 2-[methyl(p-tolyl)amino]acetonitrile (64672-68-0)

Guidance literature:

With rhodium(III) chloride hydrate; dihydrogen peroxide; In water; at 50 ℃; for 2h;

DOI:10.1016/j.tetlet.2015.05.033

Reference yield: 96.0%

trimethylsilyl cyanide (7677-24-9) + Dimethyl-p-toluidine (99-97-8) → 2-[methyl(p-tolyl)amino]acetonitrile (64672-68-0)

Guidance literature:

With tert.-butylhydroperoxide; [(bpy)AuCl₂]Cl; In methanol; decane; at 20 ℃; for 5h; regioselective reaction;

DOI:10.1039/c0cc03844j

upstream raw materials:

formaldehyd

N-methyl-p-toluidine

ethenetetracarbonitrile

Dimethyl-p-toluidine

Downstream raw materials:

N-methyl-N-phenylethylenediamine

Refernces

• 1、 -. "Synthesis method of alpha-cyanide". Paragraph 0055-0056. . Retrieved 2021/08/19.
• 2、 Yan, Fachao,Huang, Zijun,Du, Chen-Xia,Bai, Jian-Fei,Li, Yuehui. "Iron-catalyzed reductive strecker reaction". . p. 188 - 194. Retrieved 2021/02/03.