2-Thiazolidinone, 4-[(5R,8S)-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-8-methyl-1 -oxo-9-undecynyl]-3-[(4-methoxyphenyl)methyl]-, (4R)-

Base Information

Chemical Name:2-Thiazolidinone, 4-[(5R,8S)-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-8-methyl-1 -oxo-9-undecynyl]-3-[(4-methoxyphenyl)methyl]-, (4R)-
CAS No.:646994-46-9
Molecular Formula:C29H45NO5SSi
Molecular Weight:547.832
Hs Code.:

2-Thiazolidinone,
4-[(5R,8S)-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-8-methyl-1
-oxo-9-undecynyl]-3-[(4-methoxyphenyl)methyl]-, (4R)-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Thiazolidinone, 4-[(5R,8S)-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-8-methyl-1 -oxo-9-undecynyl]-3-[(4-methoxyphenyl)methyl]-, (4R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-Thiazolidinone, 4-[(5R,8S)-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-8-methyl-1 -oxo-9-undecynyl]-3-[(4-methoxyphenyl)methyl]-, (4R)-

There total 18 articles about 2-Thiazolidinone, 4-[(5R,8S)-5-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-hydroxy-8-methyl-1 -oxo-9-undecynyl]-3-[(4-methoxyphenyl)methyl]-, (4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 101860-51-9
(-)-4-acetyl-3-(4-methoxybenzyl)-thiazolidinon-2-one

: 646994-44-7
(3R,6S)-3-(tert-Butyl-dimethyl-silanyloxy)-6-methyl-non-7-ynal

: 646994-46-9
(R)-4-[(5R,8S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-8-methyl-undec-9-ynoyl]-3-(4-methoxy-benzyl)-thiazolidin-2-one

Guidance literature:: With titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at -78 ℃;
DOI:10.1002/anie.200352413

Reference yield:

: 139944-38-0
(-)-3-(4-methoxybenzyl)-2-oxo-thiazolidine-4-carboxylic acid

: 646994-46-9
(R)-4-[(5R,8S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-8-methyl-undec-9-ynoyl]-3-(4-methoxy-benzyl)-thiazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-chloro-2,N,N-trimethylprop-1-en-1-ylamine / tetrahydrofuran / 40 h / -18 °C

2.1: 0.16 g / Fe(acac)3 / tetrahydrofuran / 0.5 h / 0 °C

3.1: TiCl₄; (iPr)2NEt / CH₂Cl₂ / 2 h / 0 °C

3.2: 73 percent / CH₂Cl₂ / 3 h / -78 °C

With 1-chloro-1-(dimethylamino)-2-methyl-1-propene; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; iron(III)-acetylacetonate; In tetrahydrofuran; dichloromethane;
DOI:10.1002/chem.200601135

Reference yield:

: 646994-31-2
(S)-3-(4-Methoxy-benzyl)-2-oxo-thiazolidine-4-carbonyl chloride

: 646994-46-9
(R)-4-[(5R,8S)-5-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-8-methyl-undec-9-ynoyl]-3-(4-methoxy-benzyl)-thiazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: 0.16 g / Fe(acac)3 / tetrahydrofuran / 0.5 h / 0 °C

2.1: TiCl₄; (iPr)2NEt / CH₂Cl₂ / 2 h / 0 °C

2.2: 73 percent / CH₂Cl₂ / 3 h / -78 °C

With titanium tetrachloride; N-ethyl-N,N-diisopropylamine; iron(III)-acetylacetonate; In tetrahydrofuran; dichloromethane;
DOI:10.1002/chem.200601135