N-(mesyloxy)phthalimide

Base Information

• Chemical Name: N-(mesyloxy)phthalimide
• CAS No.: 57212-70-1
• Molecular Formula: C9H7 N O5 S
• Molecular Weight: 241.224
• European Community (EC) Number: 637-203-4
• NSC Number: 169771,96973
• DSSTox Substance ID: DTXSID20294540
• Nikkaji Number: J1.177.668J
• Wikidata: Q82033900
• ChEMBL ID: CHEMBL142025
• Mol file: 57212-70-1.mol

Synonyms:57212-70-1;N-(mesyloxy)phthalimide;2-methylsulfonyloxyisoindole-1,3-dione;1,3-Dioxoisoindolin-2-yl methanesulfonate;NSC96973;SCHEMBL66141;CHEMBL142025;n-(methylsulfonyloxy)-phthalimide;DTXSID20294540;NSC-96973;NSC169771;AKOS024332786;NSC-169771;2-[(Methanesulfonyl)oxy]-1H-isoindole-1,3(2H)-dione

Chemical Property of N-(mesyloxy)phthalimide

Chemical Property:

• Vapor Pressure: 6.75E-07mmHg at 25°C
• Boiling Point: 408.9°Cat760mmHg
• Flash Point: 201.1°C
• PSA: 89.13000
• Density: 1.64g/cm³
• LogP: 1.19250
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 241.00449350
• Heavy Atom Count: 16
• Complexity: 400

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

N-(METHYLSULFONYLOXY)-PHTHALIMIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CS(=O)(=O)ON1C(=O)C2=CC=CC=C2C1=O

Technology Process of N-(mesyloxy)phthalimide

There total 3 articles about N-(mesyloxy)phthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

N-hydroxyphthalimide (524-38-9) + methanesulfonyl chloride (124-63-0) → N-(mesyloxy)phthalimide (57212-70-1)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;

DOI:10.1016/j.bmcl.2021.128290

Reference yield:

sodium salt of 2-hydroxy-1H-isoindole-1,3(2H)-dione (70206-52-9) + methanesulfonyl chloride (124-63-0) → N-(mesyloxy)phthalimide (57212-70-1)

Guidance literature:

for 0.75h; Yield given;

DOI:10.1021/jm00386a012

Reference yield:

→ N-(mesyloxy)phthalimide (57212-70-1)

Guidance literature:

upstream raw materials:

N-hydroxyphthalimide

methanesulfonyl chloride

sodium salt of 2-hydroxy-1H-isoindole-1,3(2H)-dione

Downstream raw materials:

N-(2-(piperidine-1-carbonyl)phenyl)piperidine-1-carboxamide

methyl 2-((methoxycarbonyl)amino)benzoate

N-methoxycarbonyl-anthranilic acid-(cyclohexyl-methyl-amide)

ethyl 2-((ethoxycarbonyl)amino)benzoate