Carbamic acid, [[5-[4-[(5S)-5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophenyl] -1,3,4-thiadiazol-2-yl]methyl]methyl-, 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:Carbamic acid, [[5-[4-[(5S)-5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophenyl] -1,3,4-thiadiazol-2-yl]methyl]methyl-, 9H-fluoren-9-ylmethyl ester
CAS No.:648430-23-3
Molecular Formula:C₃₁H₂₈FN₅O₅S
Molecular Weight:601.658
Hs Code.:

Carbamic acid,
[[5-[4-[(5S)-5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophenyl]
-1,3,4-thiadiazol-2-yl]methyl]methyl-, 9H-fluoren-9-ylmethyl ester

Synonyms:

Suppliers and Price of Carbamic acid, [[5-[4-[(5S)-5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophenyl] -1,3,4-thiadiazol-2-yl]methyl]methyl-, 9H-fluoren-9-ylmethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Carbamic acid, [[5-[4-[(5S)-5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophenyl] -1,3,4-thiadiazol-2-yl]methyl]methyl-, 9H-fluoren-9-ylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Carbamic acid, [[5-[4-[(5S)-5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophenyl] -1,3,4-thiadiazol-2-yl]methyl]methyl-, 9H-fluoren-9-ylmethyl ester

There total 7 articles about Carbamic acid, [[5-[4-[(5S)-5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorophenyl] -1,3,4-thiadiazol-2-yl]methyl]methyl-, 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 77128-70-2
N-(9-fluorenylmethoxycarbonyl)sarcosine

: 648430-23-3
(5-{4-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenyl}-[1,3,4]thiadiazol-2-ylmethyl)-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; DMF

2: tetrahydrofuran / Heating

With thionyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2003.07.018

Reference yield:

: 181997-31-9
N-{[(5S)-3-(4-amino-3-fluorophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide

: 648430-23-3
(5-{4-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenyl}-[1,3,4]thiadiazol-2-ylmethyl)-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: aq. NaNO₂; aq. HCl / 1.5 h / 0 °C

1.2: 72 percent / CuCN / ethyl acetate; H₂O / 0.75 h / 0 °C

2.1: 80 percent / H₂S; triethylamine / dimethylformamide / 100 °C

3.1: tetrahydrofuran; CH₂Cl₂ / 0.5 h / 20 °C

4.1: H₂S; pyridine / tetrahydrofuran; CH₂Cl₂

5.1: 2.51 g / hydrazine monohydrate / tetrahydrofuran; CH₂Cl₂ / 1 h / 20 °C

6.1: tetrahydrofuran / Heating

With pyridine; hydrogenchloride; hydrogen sulfide; hydrazine hydrate; triethylamine; sodium nitrite; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2003.07.018

Reference yield:

: 220010-58-2
N-[[(5S)-3-[3-fluoro-4-nitrile-phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide

: 648430-23-3
(5-{4-[5-(acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenyl}-[1,3,4]thiadiazol-2-ylmethyl)-methyl-carbamic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / H₂S; triethylamine / dimethylformamide / 100 °C

2: tetrahydrofuran; CH₂Cl₂ / 0.5 h / 20 °C

3: H₂S; pyridine / tetrahydrofuran; CH₂Cl₂

4: 2.51 g / hydrazine monohydrate / tetrahydrofuran; CH₂Cl₂ / 1 h / 20 °C

5: tetrahydrofuran / Heating

With pyridine; hydrogen sulfide; hydrazine hydrate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2003.07.018