5-Benzoyl-2-(triisopropylsilyl)oxazole

Base Information

• Chemical Name: 5-Benzoyl-2-(triisopropylsilyl)oxazole
• CAS No.: 648929-24-2
• Molecular Formula: C19H27NO2Si
• Molecular Weight: 329.514
• European Community (EC) Number: 664-204-7
• DSSTox Substance ID: DTXSID00584532
• Nikkaji Number: J2.001.199H
• Wikidata: Q82476204
• Mol file: 648929-24-2.mol

Synonyms:5-Benzoyl-2-(triisopropylsilyl)oxazole;648929-24-2;phenyl-[2-tri(propan-2-yl)silyl-1,3-oxazol-5-yl]methanone;Phenyl(2-(triisopropylsilyl)oxazol-5-yl)methanone;DTXSID00584532;phenyl[2-(triisopropylsilyl)-1,3-oxazol-5-yl]methanone;Phenyl{2-[tri(propan-2-yl)silyl]-1,3-oxazol-5-yl}methanone

Chemical Property of 5-Benzoyl-2-(triisopropylsilyl)oxazole

Chemical Property:

• Melting Point: 51-55oC(lit.)
• Boiling Point: 384.0±34.0 °C(Predicted)
• PKA: -1.00±0.10(Predicted)
• Flash Point: 110oC
• PSA: 43.10000
• Density: 1.02±0.1 g/cm3(Predicted)
• LogP: 4.79140
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 329.181105638
• Heavy Atom Count: 23
• Complexity: 380

Purity/Quality:

97% ^*data from raw suppliers

5-Benzoyl-2-(triisopropylsilyl)oxazole Aldrich ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 23-24/25-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)[Si](C1=NC=C(O1)C(=O)C2=CC=CC=C2)(C(C)C)C(C)C

Technology Process of 5-Benzoyl-2-(triisopropylsilyl)oxazole

There total 1 articles about 5-Benzoyl-2-(triisopropylsilyl)oxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

benzonitrile (100-47-0) + 2-[tris(propan-2-yl)silyl]-1,3-oxazole (433332-27-5) → phenyl[2-[tris(1-methylethyl)silyl]-1,3-oxazol-5-yl]methanone (648929-24-2)

Guidance literature:

2-[tris(propan-2-yl)silyl]-1,3-oxazole; With n-butyllithium; In tetrahydrofuran; at -10 ℃;

benzonitrile; In tetrahydrofuran; at -10 - 20 ℃;

DOI:10.1021/jo051490m

Reference yield: 94.0%

phenyl[2-[tris(1-methylethyl)silyl]-1,3-oxazol-5-yl]methanone (648929-24-2) → (R)-phenyl[2-(triisopropylsilyl)-1,3-oxazol-4-yl]methanol

Guidance literature:

With (BINAP-based ligand)[(NH₂CH₂)2-based chiral ligand]RuCl₂; hydrogen; potassium carbonate; In tetrahydrofuran; isopropyl alcohol; at 25 ℃; under 2068.59 - 3102.89 Torr;

DOI:10.1021/ol0360795

Reference yield: 92.0%

phenyl[2-[tris(1-methylethyl)silyl]-1,3-oxazol-5-yl]methanone (648929-24-2) → (1,3-oxazol-5-yl)(phenyl)methanone

Guidance literature:

With hydrogenchloride; In tetrahydrofuran;

DOI:10.1021/jo051490m

upstream raw materials:

benzonitrile

2-[tris(propan-2-yl)silyl]-1,3-oxazole

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