433332-27-5

Basic information

• Product Name: 2-triisopropylsilyl oxazole
• Synonyms: 2-triisopropylsilyl oxazole
• CAS NO: 433332-27-5
• Molecular Formula: C₁₂H₂₃NOSi
• Molecular Weight: 225.40262
• Mol File: 433332-27-5.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-triisopropylsilyl oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-triisopropylsilyl oxazole(433332-27-5)
• EPA Substance Registry System: 2-triisopropylsilyl oxazole(433332-27-5)

Safety Data

• Hazardous Substances Data: 433332-27-5(Hazardous Substances Data)

Usage

General Description

2-triisopropylsilyl oxazole is a chemical compound with the molecular formula C13H23NOSi. It is a heterocyclic compound containing a five-membered ring with oxygen and nitrogen atoms. The "2-triisopropylsilyl" group is attached to the oxazole ring, providing greater stability and protecting the reactive sites in the molecule. 2-triisopropylsilyl oxazole is often used as a building block in organic synthesis, particularly in the preparation of pharmaceuticals and agrochemicals. It has also been studied for its potential antifungal and antibacterial properties. 2-triisopropylsilyl oxazole is a valuable and versatile compound in the field of organic chemistry.

Upstream product

• 288-42-6 oxazol 
• 80522-42-5 triisopropylsilyl trifluoromethanesulfonate 
• 109-72-8 n-butyllithium 
• 110-54-3 hexane 

Downstream Products

• 869542-43-8 5-(tributylstannyl)-2-(triisopropylsilyl)oxazole 
• 87150-13-8 4-(oxazol-5-yl)benzonitrile 
• 1448324-11-5 5'-{7,7-dimethoxy-5-[(4-methoxyphenyl)methoxy]hept-3-yn-2-yl}-2',3'-dihydrospiro[1,3-dioxolane-2,1'-indene]-4'-yl({2-[tris(propan-2-yl)silyl]-1,3-oxazol-5-yl})methanol 
• 869542-45-0 2-[tris(1-methylethyl)silyl]-1,3-oxazole-5-carbaldehyde 
• 648929-24-2 phenyl[2-[tris(1-methylethyl)silyl]-1,3-oxazol-5-yl]methanone 
• 869542-39-2 phenyl[2-[tris(1-methylethyl)silyl]-1,3-oxazol-5-yl]methanol 

Relevant articles and documents

Antibacterial Mimics of Natural Products by Side-Chain Functionalization of Bicyclic Tetramic Acids

Tetramic acids with unsaturated acyl chains are widely found in natural products possessing a range of biological activities, and bicyclic tetramates represent a suitable scaffold to prepare simple mimics of such complex molecules. An efficient route to functionalize the C(6)-acyl group of a bicyclic tetramate was developed and utilized to prepare a small chemical library with a range of saturated and unsaturated side-chains. The analogues with lipophilic residues possessed highly potent antibacterial activity, which was selective for Gram-positive bacteria, and the best compound was 37-fold more potent than the cephalosporin C control and with an appropriate therapeutic window.

ACC inhibitor and application thereof

The invention provides a compound suitable for being used as an acetyl CoA carboxylase (ACC) inhibitor, in particular a thienopyridine derivative, and application of the compound in preparation of medicines for treating metabolic diseases, cancers or other proliferative diseases.

COMPOSITIONS FOR THE TREATMENT OF BRAIN TUMORS

The instant invention describes pharmaceutical compositions and dosing regimens comprising radiation therapy and seviteronel with or without dexamethasone, and methods of treating diseases, disorders or symptoms thereof.