Uridine, 4-O-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-, 5'-(2-cyano-1-phenylethyl carbonate) 3'-(hydrogen butanedioate)

Base Information

Chemical Name:Uridine, 4-O-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-, 5'-(2-cyano-1-phenylethyl carbonate) 3'-(hydrogen butanedioate)
CAS No.:649759-93-3
Molecular Formula:C37H40N4O15
Molecular Weight:780.742
Hs Code.:

Uridine,
4-O-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-,
5'-(2-cyano-1-phenylethyl carbonate) 3'-(hydrogen butanedioate)

Synonyms:

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Chemical Property of Uridine, 4-O-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-, 5'-(2-cyano-1-phenylethyl carbonate) 3'-(hydrogen butanedioate)

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of Uridine, 4-O-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-, 5'-(2-cyano-1-phenylethyl carbonate) 3'-(hydrogen butanedioate)

There total 4 articles about Uridine, 4-O-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)-, 5'-(2-cyano-1-phenylethyl carbonate) 3'-(hydrogen butanedioate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 108-30-5
succinic acid anhydride

: 649759-77-3
5'-O-[(2-cyano-1-phenylethoxy)carbonyl]-O⁴-[2-(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)uridine

: 649759-93-3
5'-O-[(2-cyano-1-phenylethoxy)carbonyl]-O-⁴-[2(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)uridine 3'-(hydrogen butanedioate)

Guidance literature:: With 1-methyl-1H-imidazole; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1002/hlca.200390206

Reference yield:

: 17327-22-9
4-methoxy-2,6-dihydropyran

: 649759-93-3
5'-O-[(2-cyano-1-phenylethoxy)carbonyl]-O-⁴-[2(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)uridine 3'-(hydrogen butanedioate)

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium p-toluenesulfonate / CH₂Cl₂ / 72 h / 20 °C

1.2: 59 percent / NH₄F / methanol / 96 h / 20 °C

2.1: 59 percent / pyridine / CH₂Cl₂ / -70 - -20 °C

3.1: 99 percent / 1-methyl-1H-imidazole / CH₂Cl₂ / 18 h / 20 °C

With pyridine; 1-methyl-1H-imidazole; pyridinium p-toluenesulfonate; In dichloromethane;
DOI:10.1002/hlca.200390206

Reference yield:

: 173169-01-2
O⁴-<2-(4-nitrophenyl)ethyl>-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)uridine

: 649759-93-3
5'-O-[(2-cyano-1-phenylethoxy)carbonyl]-O-⁴-[2(4-nitrophenyl)ethyl]-2'-O-(tetrahydro-4-methoxy-2H-pyran-4-yl)uridine 3'-(hydrogen butanedioate)

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridinium p-toluenesulfonate / CH₂Cl₂ / 72 h / 20 °C

1.2: 59 percent / NH₄F / methanol / 96 h / 20 °C

2.1: 59 percent / pyridine / CH₂Cl₂ / -70 - -20 °C

3.1: 99 percent / 1-methyl-1H-imidazole / CH₂Cl₂ / 18 h / 20 °C

With pyridine; 1-methyl-1H-imidazole; pyridinium p-toluenesulfonate; In dichloromethane;
DOI:10.1002/hlca.200390206