68206-10-0Relevant academic research and scientific papers
SYNTHESES AND REACTIONS OF PYRIDAZINE DERIVATIVES XX STUDIES ON THE RADICAL METHYLATION OF THE 1,2-DIAZINE SYSTEM
Heinisch, Gottfried,Loutsch, Gerhard
, p. 1395 - 1402 (2007/10/02)
Protonated pyridazines (1,2,3) on reaction with methyl radical (generated by oxidative decarboxylation of acetic acid or by redox reaction of t-BuOOH/FeSO4*7H2O) are shown mainly to be attacked at positions β to the nitrogen atoms.However, formation of compounds 2, 4, 5, 6, 8, 9 and 10 indicates lower degree of regioselectivity compared with homolytic benzylation or acylation of the 1,2-diazine system.Synthesis of ethyl 5-styryl-4-pyridazinecarboxylates(13,14) was achieved by homolytic methylation of ethyl 4-pyridazinecarboxylate(11) followed by condensation with aromatic carbaldehydes.
