1H-Pyrazole-5-carboxylic acid, 3-[[[3-[[[2-(2-methoxyethoxy)ethoxy]acetyl]amino]-1-[(4-methoxyphenyl) methyl]-1H-pyrazol-5-yl]carbonyl]amino]-1-[(4-methoxyphenyl)methyl]-, methyl ester

Base Information

Chemical Name:1H-Pyrazole-5-carboxylic acid, 3-[[[3-[[[2-(2-methoxyethoxy)ethoxy]acetyl]amino]-1-[(4-methoxyphenyl) methyl]-1H-pyrazol-5-yl]carbonyl]amino]-1-[(4-methoxyphenyl)methyl]-, methyl ester
CAS No.:650610-01-8
Molecular Formula:C32H38N6O9
Molecular Weight:650.689
Hs Code.:

1H-Pyrazole-5-carboxylic acid,
3-[[[3-[[[2-(2-methoxyethoxy)ethoxy]acetyl]amino]-1-[(4-methoxyphenyl)
methyl]-1H-pyrazol-5-yl]carbonyl]amino]-1-[(4-methoxyphenyl)methyl]-,
methyl ester

Synonyms:

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Chemical Property of 1H-Pyrazole-5-carboxylic acid, 3-[[[3-[[[2-(2-methoxyethoxy)ethoxy]acetyl]amino]-1-[(4-methoxyphenyl) methyl]-1H-pyrazol-5-yl]carbonyl]amino]-1-[(4-methoxyphenyl)methyl]-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-5-carboxylic acid, 3-[[[3-[[[2-(2-methoxyethoxy)ethoxy]acetyl]amino]-1-[(4-methoxyphenyl) methyl]-1H-pyrazol-5-yl]carbonyl]amino]-1-[(4-methoxyphenyl)methyl]-, methyl ester

There total 6 articles about 1H-Pyrazole-5-carboxylic acid, 3-[[[3-[[[2-(2-methoxyethoxy)ethoxy]acetyl]amino]-1-[(4-methoxyphenyl) methyl]-1H-pyrazol-5-yl]carbonyl]amino]-1-[(4-methoxyphenyl)methyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 625386-12-1
5-amino-2-(p-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

: 650609-89-5
2-(4-methoxybenzyl)-5-{2-[2-(2-methoxy-ethoxy)-ethoxy]-acetylamino}-2H-pyrazole-3-carboxylic acid

: 650610-01-8
2-(4-methoxybenzyl)-5-[(2-(4-methoxybenzyl)-5-{2-[2-(2-methoxyethoxy)ethoxy]acetylamino}-2H-pyrazole-3-carbonyl)amino]-2H-pyrazole-3-carboxylic acid methyl ester

Guidance literature:: With 2-chloro-1-methyl-pyridinium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 72h;
DOI:10.1055/s-2003-41031

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 650610-01-8
2-(4-methoxybenzyl)-5-[(2-(4-methoxybenzyl)-5-{2-[2-(2-methoxyethoxy)ethoxy]acetylamino}-2H-pyrazole-3-carbonyl)amino]-2H-pyrazole-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / K₂CO₃ / dimethylformamide / 18 h / 50 °C

2: 75 percent / H₂ / 10 percent Pd/C / methanol; tetrahydrofuran

3: 53 percent / i-Pr₂NEt; 2-chloro-1-methylpyridinium chloride / CH₂Cl₂ / 18 h / 20 °C

4: 78 percent / aq. LiOH / methanol; tetrahydrofuran / 16 h

5: 66 percent / 2-chloro-1-methylpyridinium iodide; i-Pr₂NEt / CH₂Cl₂ / 72 h / 20 °C

With lithium hydroxide; 2-chloro-1-methyl-pyridinium iodide; hydrogen; 1-methyl-2-chloropyridinium chloride; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-2003-41031

Reference yield:

: 625386-10-9
2-(4-methoxybenzyl)-5-nitro-2H-pyrazole-3-carboxylic acid methyl ester

: 650610-01-8
2-(4-methoxybenzyl)-5-[(2-(4-methoxybenzyl)-5-{2-[2-(2-methoxyethoxy)ethoxy]acetylamino}-2H-pyrazole-3-carbonyl)amino]-2H-pyrazole-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 75 percent / H₂ / 10 percent Pd/C / methanol; tetrahydrofuran

2: 53 percent / i-Pr₂NEt; 2-chloro-1-methylpyridinium chloride / CH₂Cl₂ / 18 h / 20 °C

3: 78 percent / aq. LiOH / methanol; tetrahydrofuran / 16 h

4: 66 percent / 2-chloro-1-methylpyridinium iodide; i-Pr₂NEt / CH₂Cl₂ / 72 h / 20 °C

With lithium hydroxide; 2-chloro-1-methyl-pyridinium iodide; hydrogen; 1-methyl-2-chloropyridinium chloride; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1055/s-2003-41031