1,4-dibromo-2,5-bis(2-bromoethyl)benzene

Base Information

• Chemical Name: 1,4-dibromo-2,5-bis(2-bromoethyl)benzene
• CAS No.: 78965-35-2
• Molecular Formula: C10H10Br4
• Molecular Weight: 449.805
• Mol file: 78965-35-2.mol

Synonyms:

Chemical Property of 1,4-dibromo-2,5-bis(2-bromoethyl)benzene

Chemical Property:

• Vapor Pressure: 2.3E-06mmHg at 25°C
• Boiling Point: 403.8°Cat760mmHg
• Flash Point: 191.9°C
• Density: 2.103g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,4-dibromo-2,5-bis(2-bromoethyl)benzene

There total 3 articles about 1,4-dibromo-2,5-bis(2-bromoethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1,4-bis-(2-bromoethyl)benzene (4542-72-7) → 2,5-dibromo-1,4-bis(2-bromoethyl)benzene (78965-35-2)

Guidance literature:

With bromine; iodine; iron; In dichloromethane; for 114h; Ambient temperature;

DOI:10.1021/jo00335a072

Reference yield:

2-[4-(2-hydroxyethyl)phenyl]ethan-1-ol (5140-03-4) → 2,5-dibromo-1,4-bis(2-bromoethyl)benzene (78965-35-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / 48percent HBr / 15 h / Heating

2: 94 percent / Br₂, Fe, I₂ / CH₂Cl₂ / 114 h / Ambient temperature

With hydrogen bromide; bromine; iodine; iron; In dichloromethane;

DOI:10.1021/jo00335a072

Reference yield:

1,4-phenylenediacetic acid (7325-46-4) → 2,5-dibromo-1,4-bis(2-bromoethyl)benzene (78965-35-2)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethylsulfide borane complex / tetrahydrofuran / 24 h / 0 - 20 °C / Inert atmosphere

2: hydrogen bromide / water / 5 h / 100 °C / Inert atmosphere

3: iron; bromine; iodine / chloroform / 24 h / 20 °C

With dimethylsulfide borane complex; hydrogen bromide; bromine; iodine; iron; In tetrahydrofuran; chloroform; water;

upstream raw materials:

1,4-bis-(2-bromoethyl)benzene

2-[4-(2-hydroxyethyl)phenyl]ethan-1-ol

1,4-phenylenediacetic acid

Refernces

• 1、 -. "SULFONIMIDAMIDE COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY". Page/Page column 496-497. . Retrieved 2020/08/13.
• 2、 -. "COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY". Page/Page column 518; 519. . Retrieved 2019/02/13.