5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(1E,3S)-3-amino-4-hydroxy-1-butenyl]-7-[[(1,1-dimethylethoxy)carbon yl]amino]-8-oxo-, (4-methoxyphenyl)methyl ester, (6R,7R)-

Base Information

Chemical Name:5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(1E,3S)-3-amino-4-hydroxy-1-butenyl]-7-[[(1,1-dimethylethoxy)carbon yl]amino]-8-oxo-, (4-methoxyphenyl)methyl ester, (6R,7R)-
CAS No.:651059-34-6
Molecular Formula:C24H31N3O7S
Molecular Weight:505.592
Hs Code.:

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,
3-[(1E,3S)-3-amino-4-hydroxy-1-butenyl]-7-[[(1,1-dimethylethoxy)carbon
yl]amino]-8-oxo-, (4-methoxyphenyl)methyl ester, (6R,7R)-

Synonyms:

Suppliers and Price of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(1E,3S)-3-amino-4-hydroxy-1-butenyl]-7-[[(1,1-dimethylethoxy)carbon yl]amino]-8-oxo-, (4-methoxyphenyl)methyl ester, (6R,7R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(1E,3S)-3-amino-4-hydroxy-1-butenyl]-7-[[(1,1-dimethylethoxy)carbon yl]amino]-8-oxo-, (4-methoxyphenyl)methyl ester, (6R,7R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(1E,3S)-3-amino-4-hydroxy-1-butenyl]-7-[[(1,1-dimethylethoxy)carbon yl]amino]-8-oxo-, (4-methoxyphenyl)methyl ester, (6R,7R)-

There total 6 articles about 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 3-[(1E,3S)-3-amino-4-hydroxy-1-butenyl]-7-[[(1,1-dimethylethoxy)carbon yl]amino]-8-oxo-, (4-methoxyphenyl)methyl ester, (6R,7R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 651059-33-5
(6R,7R)-7-tert-Butoxycarbonylamino-3-{(E)-2-[(S)-2,2-dimethyl-3-(4-nitro-benzyloxycarbonyl)-oxazolidin-4-yl]-vinyl}-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester

: 651059-34-6
(6R,7R)-3-((E)-(S)-3-Amino-4-hydroxy-but-1-enyl)-7-tert-butoxycarbonylamino-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In methanol; for 3h;
DOI:10.1021/ja038445l

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 651059-34-6
(6R,7R)-3-((E)-(S)-3-Amino-4-hydroxy-but-1-enyl)-7-tert-butoxycarbonylamino-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 51 percent / N-trimethylsilylacetamide / CH₂Cl₂ / 20 °C

2.1: 4.5 g / NaI / butan-2-one / 20 °C

3.1: 68 percent / acetonitrile / 20 °C

4.1: potassium trimethylsilanoate / acetonitrile; CHCl₃ / 0.5 h / cooling

4.2: 77 percent / acetonitrile; CHCl₃; CH₂Cl₂ / 3 h / 20 °C

5.1: 54 percent / H₂; acetic acid / Pd/C / methanol / 3 h

With potassium trimethylsilonate; hydrogen; acetic acid; N-Trimethylsilylacetamide; sodium iodide; palladium on activated charcoal; In methanol; dichloromethane; chloroform; acetonitrile; butanone;
DOI:10.1021/ja038445l

Reference yield:

: 106773-36-8
4-methoxybenzyl-7-amino-3-chloromethyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride

: 651059-34-6
(6R,7R)-3-((E)-(S)-3-Amino-4-hydroxy-but-1-enyl)-7-tert-butoxycarbonylamino-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-methoxy-benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 51 percent / N-trimethylsilylacetamide / CH₂Cl₂ / 20 °C

2.1: 4.5 g / NaI / butan-2-one / 20 °C

3.1: 68 percent / acetonitrile / 20 °C

4.1: potassium trimethylsilanoate / acetonitrile; CHCl₃ / 0.5 h / cooling

4.2: 77 percent / acetonitrile; CHCl₃; CH₂Cl₂ / 3 h / 20 °C

5.1: 54 percent / H₂; acetic acid / Pd/C / methanol / 3 h

With potassium trimethylsilonate; hydrogen; acetic acid; N-Trimethylsilylacetamide; sodium iodide; palladium on activated charcoal; In methanol; dichloromethane; chloroform; acetonitrile; butanone;
DOI:10.1021/ja038445l