Thiazolo[4,5-c]pyridine-2-thiol

Base Information

• Chemical Name: Thiazolo[4,5-c]pyridine-2-thiol
• CAS No.: 65128-66-7
• Molecular Formula: C₆H₄N₂S₂
• Molecular Weight: 168.243
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID80570236
• Wikidata: Q82457620
• Mol file: 65128-66-7.mol

Synonyms:Thiazolo[4,5-c]pyridine-2-thiol;65128-66-7;Thiazolo[4,5-c]pyridine-2(3H)-thione;3H-[1,3]THIAZOLO[4,5-C]PYRIDINE-2-THIONE;[1,3]THIAZOLO[4,5-C]PYRIDINE-2-THIOL;1-OCTEN-3-YLBUTYRATE;SCHEMBL1761538;SCHEMBL14880785;DTXSID80570236;WWMAXWYCUREYBE-UHFFFAOYSA-N;MFCD12755949;AKOS022174559;AKOS024262722;AB65960;AS-50359;2-MERCAPTOTHIAZOLO[4,5-C]PYRIDINE;[1,3]Thiazolo[4,5-c]pyridine-2(3H)-thione;EN300-170341;O12148;F2167-8358;Z1255396445

Chemical Property of Thiazolo[4,5-c]pyridine-2-thiol

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 343.857oC at 760 mmHg
• Flash Point: 161.759oC
• PSA: 92.82000
• Density: 1.57g/cm3
• LogP: 1.98000
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 167.98159048
• Heavy Atom Count: 10
• Complexity: 160

Purity/Quality:

98%min ^*data from raw suppliers

Thiazolo[4,5-c]pyridine-2(3H)-thione 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CN=CC2=C1SC(=S)N2

Technology Process of Thiazolo[4,5-c]pyridine-2-thiol

There total 5 articles about Thiazolo[4,5-c]pyridine-2-thiol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.9%

3-amino-4-chloropyridine (20511-15-3) + potassium ethyl xanthogenate (140-89-6) → thiazolo[4,5-c]pyridine-2(3H)-thione (65128-66-7)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 1h; Microwave irradiation;

Reference yield: 70.0%

3-amino-4-chloropyridine (20511-15-3) + potassium ethyl xanthogenate (140-89-6) → 2-mercapto-pyrido[3,4-d][1,3]thiazole (65128-66-7)

Guidance literature:

3-amino-4-chloropyridine; potassium ethyl xanthogenate; In N,N-dimethyl-formamide; at 95 - 100 ℃; for 15h;

With hydrogenchloride; In water; N,N-dimethyl-formamide; for 0.5h;

Reference yield: 46.0%

carbon disulfide (75-15-0,12122-00-8) + 4-chloro-3-nitropyridine (13091-23-1) → thiazolo[4,5-c]pyridine-2(3H)-thione (65128-66-7)

Guidance literature:

With sodium hydroxide; hydrogen sulfide; In water; at 45 - 110 ℃; for 8h;

DOI:10.1016/j.ejmech.2004.09.010

upstream raw materials:

carbon disulfide

4-chloro-3-nitropyridine

3-aminopyridine-4(1H)-thione

3-amino-4-chloropyridine

Downstream raw materials:

3H-thiazolo[4,5-c]pyridin-2-one

2-(methylthio)thiazolo[4,5-c]pyridine

2-chlorothiazolo[4,5-c]pyridine

N-(4-bromophenyl)thiazolo[4,5-c]pyridin-2-ylamine