1-Cyclohexene-1-carboxylic acid, 5-[(1,1-dimethylethyl)amino]-3-(1-ethylpropoxy)-4-hydroxy-, ethyl ester, (3R,4S,5R)-

Base Information

Chemical Name:1-Cyclohexene-1-carboxylic acid, 5-[(1,1-dimethylethyl)amino]-3-(1-ethylpropoxy)-4-hydroxy-, ethyl ester, (3R,4S,5R)-
CAS No.:651324-04-8
Molecular Formula:C18H33NO4
Molecular Weight:327.464
Hs Code.:

Synonyms:ethyl (3R,4S,5R)-5-N-(1,1-dimethylethyl)amino-3-(1-ethylpropoxy)-4-hydroxy-cyclohexene-1-carboxylate;

Suppliers and Price of 1-Cyclohexene-1-carboxylic acid, 5-[(1,1-dimethylethyl)amino]-3-(1-ethylpropoxy)-4-hydroxy-, ethyl ester, (3R,4S,5R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 11 raw suppliers

Chemical Property of 1-Cyclohexene-1-carboxylic acid, 5-[(1,1-dimethylethyl)amino]-3-(1-ethylpropoxy)-4-hydroxy-, ethyl ester, (3R,4S,5R)-

Chemical Property:

Boiling Point:425.7±45.0 °C(Predicted)
PSA：67.79000
Density:1.03±0.1 g/cm3(Predicted)
LogP:2.96190

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-Cyclohexene-1-carboxylic acid, 5-[(1,1-dimethylethyl)amino]-3-(1-ethylpropoxy)-4-hydroxy-, ethyl ester, (3R,4S,5R)-

There total 4 articles about 1-Cyclohexene-1-carboxylic acid, 5-[(1,1-dimethylethyl)amino]-3-(1-ethylpropoxy)-4-hydroxy-, ethyl ester, (3R,4S,5R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.1%

: 757965-01-8,1217834-81-5,1266663-89-1,2413185-89-2
(1S,5R,6R)-5-(1-ethyl-propoxy)-7-oxa-bicyclo[4.1.0]hept-3-ene-3-carboxylic acid ethyl ester

: 75-64-9
tert-butylamine

: 651324-04-8
(3R,4S,5R)-[5-(tert-butylamino)-4-hydroxy-3-(pent-3-yloxy)]cyclohex-1-ene-1-carboxylic acid ethyl ester

Guidance literature:: tert-butylamine; With magnesium chloride; In toluene; at 25 ℃; for 6h;

(1S,5R,6R)-5-(1-ethyl-propoxy)-7-oxa-bicyclo[4.1.0]hept-3-ene-3-carboxylic acid ethyl ester; In toluene; at 20 - 50 ℃; for 20h;
DOI:10.1021/op0302107

Reference yield: 96.1%

: 757965-01-8,1217834-81-5,1266663-89-1,2413185-89-2
(1S,5R,6R)-5-(1-ethyl-propoxy)-7-oxa-bicyclo[4.1.0]hept-3-ene-3-carboxylic acid ethyl ester

: C₄H₁₁N*Br₂Mg

: 651324-04-8
(3R,4S,5R)-[5-(tert-butylamino)-4-hydroxy-3-(pent-3-yloxy)]cyclohex-1-ene-1-carboxylic acid ethyl ester

Guidance literature:: In toluene; at 20 - 50 ℃; for 20 - 23h; Product distribution / selectivity;

Reference yield: 95.8%

: 75-64-9
tert-butylamine

: 204254-96-6,1217834-81-5,1266663-89-1,2413185-89-2
(1S,5R,6S)-5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic acid ethyl ester

: 1151665-78-9
C₁₄H₂₀O₃

: C₁₄H₂₃ClO₄

: 651324-04-8
(3R,4S,5R)-[5-(tert-butylamino)-4-hydroxy-3-(pent-3-yloxy)]cyclohex-1-ene-1-carboxylic acid ethyl ester

Guidance literature:: tert-butylamine; With magnesium chloride; In toluene; at 10 ℃; for 1h;

(1S,5R,6S)-5-(pentan-3-yloxy)-7-oxabicyclo[4.1.0]hept-3-ene-3-carboxylic acid ethyl ester; In toluene; at 60 ℃; for 48h; Temperature; Time;