1H-Indole-3-carboxaldehyde, 4-methoxy-1-[(4-methoxyphenyl)sulfonyl]-

Base Information

Chemical Name:1H-Indole-3-carboxaldehyde, 4-methoxy-1-[(4-methoxyphenyl)sulfonyl]-
CAS No.:651331-49-6
Molecular Formula:C17H15NO5S
Molecular Weight:345.376
Hs Code.:
DSSTox Substance ID:DTXSID80463179
Wikidata:Q82287996

Synonyms:651331-49-6;4-methoxy-1-((4-methoxyphenyl)sulfonyl)-1H-indole-3-carbaldehyde;4-methoxy-1-(4-methoxybenzenesulfonyl)-1H-indole-3-carbaldehyde;1H-Indole-3-carboxaldehyde, 4-methoxy-1-[(4-methoxyphenyl)sulfonyl]-;SCHEMBL5368507;DTXSID80463179

Suppliers and Price of 1H-Indole-3-carboxaldehyde, 4-methoxy-1-[(4-methoxyphenyl)sulfonyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 1H-Indole-3-carboxaldehyde, 4-methoxy-1-[(4-methoxyphenyl)sulfonyl]-

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:345.06709375
Heavy Atom Count:24
Complexity:538

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)S(=O)(=O)N2C=C(C3=C2C=CC=C3OC)C=O

Technology Process of 1H-Indole-3-carboxaldehyde, 4-methoxy-1-[(4-methoxyphenyl)sulfonyl]-

There total 6 articles about 1H-Indole-3-carboxaldehyde, 4-methoxy-1-[(4-methoxyphenyl)sulfonyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 90734-97-7
4-methoxyindole-3-carboxaldehyde

: 98-68-0
4-methoxy-phenyl-sulphonyl chloride

: 651331-49-6
4-methoxy-1-(4-methoxybenzenesulfonyl)-1H-indole-3-carbaldehyde

Guidance literature:: 4-methoxyindole-3-carboxaldehyde; With sodium hydroxide; In dichloromethane; at 20 ℃; for 0.5h;

4-methoxy-phenyl-sulphonyl chloride; In dichloromethane; at 20 ℃; for 12h;
DOI:10.1021/jm0493616

Reference yield:

: 4837-90-5
4-methoxy-1H-indole

: 651331-49-6
4-methoxy-1-(4-methoxybenzenesulfonyl)-1H-indole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85 percent / phosphoryl chloride / 1.5 h / 0 - 40 °C

2.1: NaOH / CH₂Cl₂ / 0.5 h / 20 °C

2.2: 97 percent / CH₂Cl₂ / 12 h / 20 °C

With sodium hydroxide; trichlorophosphate; In dichloromethane; 1.1: Vilsmeier formylation;
DOI:10.1021/jm0493616

Reference yield:

: 103260-65-7
4-methoxy-1H-indole-2-carboxylic acid

: 651331-49-6
4-methoxy-1-(4-methoxybenzenesulfonyl)-1H-indole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: 94 percent / Cu; quinoline / 2 h / Heating

2.1: 85 percent / phosphoryl chloride / 1.5 h / 0 - 40 °C

3.1: NaOH / CH₂Cl₂ / 0.5 h / 20 °C

3.2: 97 percent / CH₂Cl₂ / 12 h / 20 °C

With quinoline; sodium hydroxide; copper; trichlorophosphate; In dichloromethane; 2.1: Vilsmeier formylation;
DOI:10.1021/jm0493616