N-ACETYL-5-METHOXY-DL-TRYPTOPHAN MONOHYDRATE

Base Information

• Chemical Name: N-ACETYL-5-METHOXY-DL-TRYPTOPHAN MONOHYDRATE
• CAS No.: 43167-40-4
• Molecular Formula: C14H16N2O4
• Molecular Weight: 276.2878
• Hs Code.: 2933990090
• Mol file: 43167-40-4.mol

Synonyms:N-ACETYL-5-METHOXY-L-TRYPTOPHAN;Tryptophan,N-acetyl-5-methoxy;N-Acetyl-5-methoxytryptophan;

Chemical Property of N-ACETYL-5-METHOXY-DL-TRYPTOPHAN MONOHYDRATE

Chemical Property:

• Vapor Pressure: 1.12E-15mmHg at 25°C
• Melting Point: 182-183 °C
• Boiling Point: 608.8°Cat760mmHg
• PKA: 3.52±0.10(Predicted)
• Flash Point: 322°C
• PSA: 100.65000
• Density: 1.321g/cm³
• LogP: 1.63490

Purity/Quality:

98%Min ^*data from raw suppliers

2-Acetamido-3-(5-methoxy-1H-indol-3-yl)propanoicacid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-ACETYL-5-METHOXY-DL-TRYPTOPHAN MONOHYDRATE

There total 7 articles about N-ACETYL-5-METHOXY-DL-TRYPTOPHAN MONOHYDRATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

5-methoxylindole (1006-94-6) + L-serin (56-45-1,83245-15-2) + acetic anhydride (108-24-7) → Nα-acetyl-5-methoxy-D,L-tryptophan (43167-40-4,114926-33-9)

Guidance literature:

With acetic acid; at 73 ℃; for 2h;

DOI:10.1016/j.tetlet.2008.02.120

Reference yield: 76.0%

acetylamino-(5-methoxy-indol-3-ylmethyl)-malonic acid (54744-68-2) → Nα-acetyl-5-methoxy-D,L-tryptophan (43167-40-4,114926-33-9)

Guidance literature:

In water; for 3h; Reflux;

Reference yield:

acetylamino-(5-methoxy-indol-3-ylmethyl)-malonic acid diethyl ester (54744-69-3) → Nα-acetyl-5-methoxy-D,L-tryptophan (43167-40-4,114926-33-9)

Guidance literature:

With sodium hydroxide; Erhitzen des Reaktionsprodukts mit H₂O;

upstream raw materials:

acetylamino-(5-methoxy-indol-3-ylmethyl)-malonic acid diethyl ester

5-methoxylindole

5-methoxygramine

L-serin

Downstream raw materials:

N^α-acetyl-5-methoxy-D-tryptophan

5-methoxy-DL-tryptophan