Technology Process of 2(3H)-Furanone,dihydro-5-[7-methoxy-6-(3,- 4,5-trimethoxyphenyl)-1,3-benzodioxol-5-yl]- 4-methyl-3-methylene-,(4R,5S)-rel-
There total 9 articles about 2(3H)-Furanone,dihydro-5-[7-methoxy-6-(3,- 4,5-trimethoxyphenyl)-1,3-benzodioxol-5-yl]- 4-methyl-3-methylene-,(4R,5S)-rel- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene;
In
dichloromethane;
at 20 ℃;
for 4.5h;
Inert atmosphere;
DOI:10.1002/ejoc.201201247
- Guidance literature:
-
Multi-step reaction with 6 steps
1: diisobutylaluminium hydride / toluene / -78 °C
2: CyJohnPhos; potassium phosphate; palladium diacetate / toluene / 80 °C / Inert atmosphere
3: potassium tert-butylate / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere
4: n-butyllithium; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline] / diethyl ether; hexane / 8 h / -78 °C / Inert atmosphere
5: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
6: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 4.5 h / 20 °C / Inert atmosphere
With
potassium phosphate; n-butyllithium; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; potassium tert-butylate; tetrabutyl ammonium fluoride; palladium diacetate; diisobutylaluminium hydride; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline]; CyJohnPhos;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; toluene;
2: |Suzuki Coupling / 3: |Williamson Ether Synthesis / 4: |[2,3]-Wittig Rearrangement;
DOI:10.1002/ejoc.201201247
- Guidance literature:
-
Multi-step reaction with 4 steps
1: potassium tert-butylate / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere
2: n-butyllithium; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline] / diethyl ether; hexane / 8 h / -78 °C / Inert atmosphere
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere
4: 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene / dichloromethane / 4.5 h / 20 °C / Inert atmosphere
With
n-butyllithium; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; [bis(acetoxy)iodo]benzene; potassium tert-butylate; tetrabutyl ammonium fluoride; 2,2'-isopropylidenebis[(4S)-4-tert-butyl-2-oxazoline];
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane;
1: |Williamson Ether Synthesis / 2: |[2,3]-Wittig Rearrangement;
DOI:10.1002/ejoc.201201247
