(1R,2R)-1-Fluoro-2-methoxycyclohexane

Base Information

• Chemical Name: (1R,2R)-1-Fluoro-2-methoxycyclohexane
• CAS No.: 65267-06-3
• Molecular Formula: C₇H₁₃FO
• Molecular Weight: 132.178
• DSSTox Substance ID: DTXSID90507356
• Nikkaji Number: J755.446J
• Mol file: 65267-06-3.mol

Synonyms:(1R,2R)-1-Fluoro-2-methoxycyclohexane;65267-06-3;DTXSID90507356

Chemical Property of (1R,2R)-1-Fluoro-2-methoxycyclohexane

Chemical Property:

• Boiling Point: 45 °C(Press: 20 Torr)
• PSA: 9.23000
• Density: 0.95±0.1 g/cm3(Predicted)
• LogP: 1.91350
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 132.095043196
• Heavy Atom Count: 9
• Complexity: 85

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1CCCCC1F
• Isomeric SMILES: CO[C@@H]1CCCC[C@H]1F

Technology Process of (1R,2R)-1-Fluoro-2-methoxycyclohexane

There total 6 articles about (1R,2R)-1-Fluoro-2-methoxycyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trans-2-methoxycyclohexyl-mercury(II) chloride (5274-83-9) → trans-2-fluoro-1-methoxycyclohexane (65267-06-3,79186-49-5)

Guidance literature:

With N-fluorobis<(trifluoromethyl)sulfonyl>imide; In acetonitrile; at -40 - 23 ℃; for 1h;

DOI:10.1016/S0022-1139(99)00231-6

Reference yield:

Toluene-4-sulfonic acid 2-methoxy-cyclohexyl ester → trans-2-fluoro-1-methoxycyclohexane (65267-06-3,79186-49-5) + fluoro-1, methoxy-2 cyclohexane (Z)

Guidance literature:

With potassium fluoride; In diethylene glycol; at 150 ℃; for 2h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/S0022-1139(00)82301-5

Reference yield:

2-fluoro-cyclohexanol (14365-32-3,20421-48-1,75024-00-9,656-60-0) + methyl iodide (74-88-4) → trans-2-fluoro-1-methoxycyclohexane (65267-06-3,79186-49-5)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 80 ℃; for 6h; Yield given;

DOI:10.1016/S0022-1139(00)82301-5

upstream raw materials:

methanol

cyclohexene

methyl hypofluorite

2-fluoro-cyclohexanol