2-Butanone, 3-[(2R,4R)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-, (3R)-

Base Information

Chemical Name:2-Butanone, 3-[(2R,4R)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-, (3R)-
CAS No.:652986-40-8
Molecular Formula:C15H20O4
Molecular Weight:264.321
Hs Code.:
DSSTox Substance ID:DTXSID40477196
Nikkaji Number:J2.001.667A
Wikidata:Q82309496

Synonyms:652986-40-8;2-Butanone, 3-[(2R,4R)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-, (3R)-;DTXSID40477196

Suppliers and Price of 2-Butanone, 3-[(2R,4R)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-, (3R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 2-Butanone, 3-[(2R,4R)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-, (3R)-

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:264.13615911
Heavy Atom Count:19
Complexity:297

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1CCOC(O1)C2=CC=C(C=C2)OC)C(=O)C
Isomeric SMILES:C[C@H]([C@H]1CCO[C@H](O1)C2=CC=C(C=C2)OC)C(=O)C

Technology Process of 2-Butanone, 3-[(2R,4R)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-, (3R)-

There total 3 articles about 2-Butanone, 3-[(2R,4R)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]-, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128461-65-4
3-(p-methoxybenzyloxy)propanal

: 652986-40-8
(R)-3-[(2R,4R)-2-(4-Methoxy-phenyl)-[1,3]dioxan-4-yl]-butan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-Bu₂BOTf; DIPEA / diethyl ether / -78 °C

1.2: DDQ; 4 Angstroem molecular sieves / CH₂Cl₂ / 3 h / 0 - 20 °C

2.1: LiBH₄ / diethyl ether; H₂O / 1 h / 0 °C

3.2: diethyl ether / 1 h / 0 °C

With lithium borohydride; di-n-butylboryl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine; In diethyl ether; water; 3.1: Swern oxidation / 3.3: Swern oxidation;
DOI:10.1021/ol036229b

Reference yield:

: 652986-80-6
(S)-4-Benzyl-3-{(R)-2-[(2R,4R)-2-(4-methoxy-phenyl)-[1,3]dioxan-4-yl]-propionyl}-oxazolidin-2-one

: 652986-40-8
(R)-3-[(2R,4R)-2-(4-Methoxy-phenyl)-[1,3]dioxan-4-yl]-butan-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: LiBH₄ / diethyl ether; H₂O / 1 h / 0 °C

2.2: diethyl ether / 1 h / 0 °C

With lithium borohydride; In diethyl ether; water; 2.1: Swern oxidation / 2.3: Swern oxidation;
DOI:10.1021/ol036229b

Reference yield:

: 917-64-6
methyl magnesium iodide

: 507480-05-9
(2S)-2-[(4R)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]propan-1-ol

: 652986-40-8
(R)-3-[(2R,4R)-2-(4-Methoxy-phenyl)-[1,3]dioxan-4-yl]-butan-2-one

Guidance literature:: (2S)-2-[(4R)-2-(4-methoxyphenyl)-1,3-dioxan-4-yl]propan-1-ol;

methyl magnesium iodide; In diethyl ether; at 0 ℃; for 1h;

DOI:10.1021/ol036229b