Z-Tyr-NH2

Base Information

• Chemical Name: Z-Tyr-NH2
• CAS No.: 19898-39-6
• Molecular Formula: C17H18N2O4
• Molecular Weight: 314.341
• Nikkaji Number: J577.224I
• ChEMBL ID: CHEMBL65770
• Mol file: 19898-39-6.mol

Synonyms:19898-39-6;Z-TYR-NH2;Z-L-tyrosine amide;CHEMBL65770;Carbamic acid, N-[(1S)-2-amino-1-[(4-hydroxyphenyl)methyl]-2-oxoethyl]-, phenylmethyl ester;(S)-Benzyl (1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate;BENZYL N-[(1S)-1-CARBAMOYL-2-(4-HYDROXYPHENYL)ETHYL]CARBAMATE;BDBM50043817;MFCD00136595;AS-74441;EN300-7383683;J-012854;(S)-benzyl 1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-ylcarbamate;(S)-Benzyl(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate;[(S)-1-Carbamoyl-2-(4-hydroxy-phenyl)-ethyl]-carbamic acid benzyl ester;Benzyl (S)-(1-amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate

Chemical Property of Z-Tyr-NH2

Chemical Property:

• Vapor Pressure: 1.76E-15mmHg at 25°C
• Boiling Point: 610.2°Cat760mmHg
• Flash Point: 322.8°C
• PSA: 101.65000
• Density: 1.286g/cm³
• LogP: 2.80620
• Storage Temp.: Store at RT.
• XLogP3: 1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 7
• Exact Mass: 314.12665706
• Heavy Atom Count: 23
• Complexity: 388

Purity/Quality:

98% ^*data from raw suppliers

Z-L-tyrosine amide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)NC(CC2=CC=C(C=C2)O)C(=O)N
• Isomeric SMILES: C1=CC=C(C=C1)COC(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N

Technology Process of Z-Tyr-NH2

There total 7 articles about Z-Tyr-NH2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

Z-L-Tyr-OH (1164-16-5) → N-Carbobenzyloxy-L-tyrosinamide (19898-39-6)

Guidance literature:

Z-L-Tyr-OH; With 4-methyl-morpholine; isobutyl chloroformate; In dichloromethane; at 0 ℃; for 0.833333h;

With ammonium hydroxide; In dichloromethane; at 0 - 25 ℃; for 16.0833h;

DOI:10.1021/acs.jmedchem.8b01466

Reference yield:

tyrosamine (51-67-2) + benzyl chloroformate (501-53-1,94274-21-2) → N-Carbobenzyloxy-L-tyrosinamide (19898-39-6)

Guidance literature:

With sodium hydrogencarbonate; In water;

Reference yield:

Boc-Tyr-OSu (80140-62-1) → N-Carbobenzyloxy-L-tyrosinamide (19898-39-6)

Guidance literature:

With ammonia; In dichloromethane; at 0 ℃; for 0.0833333h; Yield given;

DOI:10.1016/S0040-4020(99)00177-5

upstream raw materials:

4-nitrophenyl N-[(benzyloxy)carbonyl]-L-tyrosinate

Boc-Tyr-OSu

Z-L-Tyr-OH

L-tyrosine

Downstream raw materials:

Z-L-Tyr-OH

N-(benzyloxycarbonyl)-L-tyrosine methyl ester

[(S)-1-Carbamoyl-2-(4-methoxy-phenyl)-ethyl]-carbamic acid benzyl ester

Refernces

• 1、 Yamawaki, Mugen,Okita, Yoshiki,Yamamoto, Takashi,Morita, Toshio,Yoshimi, Yasuharu. "Photoinduced electron transfer-promoted debenzylation of phenylalanine and tyrosine derivatives using dicyanoarene". . p. 7239 - 7244. Retrieved 2017/11/20.
• 2、 -. "Anti-atherosclerotic aryl compounds". . . Retrieved 2008/06/13.