Methanone, (3-fluorophenyl)[2-[4-(methylthio)phenyl]-3-pyridinyl]-

Base Information

Chemical Name:Methanone, (3-fluorophenyl)[2-[4-(methylthio)phenyl]-3-pyridinyl]-
CAS No.:654059-05-9
Molecular Formula:C19H14FNOS
Molecular Weight:323.391
Hs Code.:
DSSTox Substance ID:DTXSID90464556
Wikidata:Q82289925

Synonyms:654059-05-9;Methanone, (3-fluorophenyl)[2-[4-(methylthio)phenyl]-3-pyridinyl]-;SCHEMBL4958812;DTXSID90464556

Suppliers and Price of Methanone, (3-fluorophenyl)[2-[4-(methylthio)phenyl]-3-pyridinyl]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Methanone, (3-fluorophenyl)[2-[4-(methylthio)phenyl]-3-pyridinyl]-

Chemical Property:

XLogP3:4.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:323.07801341
Heavy Atom Count:23
Complexity:397

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CSC1=CC=C(C=C1)C2=C(C=CC=N2)C(=O)C3=CC(=CC=C3)F

Technology Process of Methanone, (3-fluorophenyl)[2-[4-(methylthio)phenyl]-3-pyridinyl]-

There total 3 articles about Methanone, (3-fluorophenyl)[2-[4-(methylthio)phenyl]-3-pyridinyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 654059-02-6
2-chloro-(3-pyridyl) 3-fluorophenyl ketone

: 98546-51-1
(4-thiomethoxyphenyl)boronic acid

: 654059-05-9
3-fluorophenyl 2-(4-methylthiophenyl)(3-pyridyl) ketone

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; toluene; Heating;
DOI:10.1021/jm0582064

Reference yield:

: 49609-84-9
2-Chloronicotinoyl chloride

: 654059-05-9
3-fluorophenyl 2-(4-methylthiophenyl)(3-pyridyl) ketone

Guidance literature:: Multi-step reaction with 2 steps

1.1: Mg; I₂ / tetrahydrofuran / Heating

1.2: 2.35 g / tetrahydrofuran / 0.25 h / 20 °C

2.1: 46 percent / Na₂CO₃; Pd(PPh₃)4 / toluene; ethanol / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; sodium carbonate; magnesium; In tetrahydrofuran; ethanol; toluene; 2.1: Suzuki-Miyaura coupling;
DOI:10.1021/jm0582064

Reference yield:

: 1073-06-9
3-fluorobromobenzene

: 654059-05-9
3-fluorophenyl 2-(4-methylthiophenyl)(3-pyridyl) ketone

Guidance literature:: Multi-step reaction with 2 steps

1.1: Mg; I₂ / tetrahydrofuran / Heating

1.2: 2.35 g / tetrahydrofuran / 0.25 h / 20 °C

2.1: 46 percent / Na₂CO₃; Pd(PPh₃)4 / toluene; ethanol / Heating

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; sodium carbonate; magnesium; In tetrahydrofuran; ethanol; toluene; 2.1: Suzuki-Miyaura coupling;
DOI:10.1021/jm0582064