Ethyl 6-(chloromethyl)-2,3-dimethoxybenzoate

Base Information

Chemical Name:Ethyl 6-(chloromethyl)-2,3-dimethoxybenzoate
CAS No.:65495-31-0
Molecular Formula:C12H15ClO4
Molecular Weight:258.702
Hs Code.:
DSSTox Substance ID:DTXSID501259564
Nikkaji Number:J1.395.068G

Synonyms:ethyl 6-(chloromethyl)-2,3-dimethoxybenzoate;65495-31-0;DTXSID501259564;6-(chloromethyl)-2,3-dimethoxybenzoic acid ethylester;6-(chloromethyl)-2,3-dimethoxy-benzoic acid ethyl ester

Suppliers and Price of Ethyl 6-(chloromethyl)-2,3-dimethoxybenzoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 6-(chloromethyl)-2,3-dimethoxybenzoate

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:258.0658866
Heavy Atom Count:17
Complexity:247

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=C(C=CC(=C1OC)OC)CCl

Technology Process of Ethyl 6-(chloromethyl)-2,3-dimethoxybenzoate

There total 4 articles about Ethyl 6-(chloromethyl)-2,3-dimethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 65495-21-8
N,N-dimethyl-3,4-dimethoxybenzylamine

: 541-41-3
chloroformic acid ethyl ester

: 65495-31-0
6-(chloromethyl)-2,3-dimethoxybenzoic acid ethyl ester

Guidance literature:: With n-butyllithium; Yield given. Multistep reaction; 1.) THF, hexane, 20 deg C, 1.5 h, 2.) 20 deg C, 24 h;
DOI:10.1071/CH9810383

Reference yield:

: 86633-32-1
ethyl 2-(methoxymethyl)-5,6-dimethoxybenzoate

: 65495-31-0
6-(chloromethyl)-2,3-dimethoxybenzoic acid ethyl ester

Guidance literature:: With acetyl chloride; zinc(II) chloride; In diethyl ether; for 0.5h; Yield given; ice cooling;
DOI:10.1021/jo00169a007

Reference yield:

: 3840-28-6
1,2-dimethoxy-4-(methoxymethyl)benzene

: 65495-31-0
6-(chloromethyl)-2,3-dimethoxybenzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1) n-butyllithium / 1) ether, ice-water cooling, 1 h, 2) dry ice-acetone bath

2: acetyl chloride, ZnCl₂ / diethyl ether / 0.5 h / ice cooling

With n-butyllithium; acetyl chloride; zinc(II) chloride; In diethyl ether;
DOI:10.1021/jo00169a007