1,2-Dimethoxy-4-(methoxymethyl)benzene

Base Information

• Chemical Name: 1,2-Dimethoxy-4-(methoxymethyl)benzene
• CAS No.: 3840-28-6
• Molecular Formula: C10H14O3
• Molecular Weight: 182.219
• Hs Code.: 2909309090
• DSSTox Substance ID: DTXSID00191740
• Nikkaji Number: J590.650D
• Wikidata: Q27159297

Synonyms:1,2-dimethoxy-4-(methoxymethyl)benzene;3,4-Dimethoxybenzyl methyl ether;3840-28-6;veratryl alcohol methyl ether;Benzene, 1,2-dimethoxy-4-(methoxymethyl)-;SCHEMBL291363;CHEBI:86961;DTXSID00191740;methyl 3,4-dimethoxybenzyl ether;Benzene, 1,2-dimethoxy-4-(methoxymethyl);Q27159297

Chemical Property of 1,2-Dimethoxy-4-(methoxymethyl)benzene

Chemical Property:

• Vapor Pressure: 0.066mmHg at 25°C
• Boiling Point: 238.3°C at 760 mmHg
• Flash Point: 77.7°C
• PSA: 27.69000
• Density: 1.031g/cm³
• LogP: 1.85020
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 182.094294304
• Heavy Atom Count: 13
• Complexity: 138

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC1=CC(=C(C=C1)OC)OC

Technology Process of 1,2-Dimethoxy-4-(methoxymethyl)benzene

There total 14 articles about 1,2-Dimethoxy-4-(methoxymethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(3,4-dimethoxyphenyl)methanol (93-03-8) + methyl iodide (74-88-4) → 1,2-dimethoxy-4-(methoxymethyl)benzene (3840-28-6)

Guidance literature:

(3,4-dimethoxyphenyl)methanol; With sodium hydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere; Schlenk technique;

methyl iodide; In tetrahydrofuran; at 0 - 20 ℃; for 3h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.bioorg.2021.105388

Reference yield: 78.0%

3,4-dimethoxy-benzaldehyde (120-14-9) + trimethyl orthoformate (149-73-5) → 1,2-dimethoxy-4-(methoxymethyl)benzene (3840-28-6)

Guidance literature:

With C₁₈H₄BCl₃F₈; hydrogen; In tetrahydrofuran; at 55 ℃; for 48h; under 15001.5 Torr;

DOI:10.1002/anie.201700231

Reference yield:

veratryl acetate (53751-40-9) → 1,2-bis(3,4-dimethoxyphenyl)ethane (5963-51-9) + 1,2-dimethoxy-4-methylbenzene (494-99-5) + 1,2-dimethoxy-4-(methoxymethyl)benzene (3840-28-6) + 4-ethylveratrole (5888-51-7)

Guidance literature:

In methanol; Irradiation;

DOI:10.1021/jo00098a016

upstream raw materials:

methanol

4-chloromethyl-1,2-dimethoxy-benzene

1-bromo-3,4-dimethoxy-6-(methoxymethyl)benzene

acetonitrile

Downstream raw materials:

cyclotriveratrylene

(3,4-dimethoxyphenyl)methanol

6,7-dimethoxy-4-phenyl-2-tosyl-1,2,3,4-tetrahydroisoquinoline

C₁₈H₁₆ClFN₂O₇S

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