N-[(1R)-1-(4-bromophenyl)ethyl]-4-chloro-3-nitropyridin-2-amine

Base Information

Chemical Name:N-[(1R)-1-(4-bromophenyl)ethyl]-4-chloro-3-nitropyridin-2-amine
CAS No.:656237-77-3
Molecular Formula:C13H11BrClN3O2
Molecular Weight:356.606
Hs Code.:
DSSTox Substance ID:DTXSID60465272
Wikidata:Q82291092

Synonyms:656237-77-3;N-[(1R)-1-(4-bromophenyl)ethyl]-4-chloro-3-nitropyridin-2-amine;SCHEMBL6708441;DTXSID60465272

Suppliers and Price of N-[(1R)-1-(4-bromophenyl)ethyl]-4-chloro-3-nitropyridin-2-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[(1R)-1-(4-bromophenyl)ethyl]-4-chloro-3-nitropyridin-2-amine

Chemical Property:

XLogP3:4.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:354.97232
Heavy Atom Count:20
Complexity:334

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C1=CC=C(C=C1)Br)NC2=NC=CC(=C2[N+](=O)[O-])Cl
Isomeric SMILES:C[C@H](C1=CC=C(C=C1)Br)NC2=NC=CC(=C2[N+](=O)[O-])Cl

Technology Process of N-[(1R)-1-(4-bromophenyl)ethyl]-4-chloro-3-nitropyridin-2-amine

There total 4 articles about N-[(1R)-1-(4-bromophenyl)ethyl]-4-chloro-3-nitropyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[(R)-1-(4-Bromo-phenyl)-ethylamino]-3-nitro-pyridin-4-ol

: 656237-77-3
N-[(1R)-1-(4-bromophenyl)ethyl]-4-chloro-3-nitropyridin-2-amine

Guidance literature:: With trichlorophosphate; In acetonitrile; at 80 ℃; for 3h;
DOI:10.1021/jm049394l

Reference yield:

: 24358-62-1,27298-97-1,45791-36-4,64313-06-0
(R)-1-(4-bromophenyl)ethylamine

: 629655-23-8
2-chloro-3-nitro-4-hydroxypyridine

: 656237-77-3
N-[(1R)-1-(4-bromophenyl)ethyl]-4-chloro-3-nitropyridin-2-amine

Guidance literature:: (R)-1-(4-bromophenyl)ethylamine; 2-chloro-3-nitro-4-hydroxypyridine; With triethylamine; In butan-1-ol; at 110 ℃; for 48h;

With trichlorophosphate; In acetonitrile; at 80 ℃; for 3h;

Reference yield:

: 24358-62-1,27298-97-1,45791-36-4,64313-06-0
(R)-1-(4-bromophenyl)ethylamine

: 656237-77-3
N-[(1R)-1-(4-bromophenyl)ethyl]-4-chloro-3-nitropyridin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / butan-1-ol / 48 h / 110 °C

2: POCl₃ / acetonitrile / 3 h / 80 °C

With triethylamine; trichlorophosphate; In acetonitrile; butan-1-ol;
DOI:10.1021/jm049394l