1-(10-Methyl-10H-phenothiazin-2-yl)ethan-1-one

Base Information

Chemical Name:1-(10-Methyl-10H-phenothiazin-2-yl)ethan-1-one
CAS No.:25324-52-1
Molecular Formula:C15H13 N O S
Molecular Weight:255.34
Hs Code.:2934300000
European Community (EC) Number:246-847-1
DSSTox Substance ID:DTXSID60179968
Nikkaji Number:J250.428F
Wikidata:Q27210377
Pharos Ligand ID:AXZ1V4Y3Z3L5
ChEMBL ID:CHEMBL1362864
Mol file:25324-52-1.mol

Synonyms:25324-52-1;1-(10-methyl-10H-phenothiazin-2-yl)ethanone;1-(10-Methyl-10H-phenothiazin-2-yl)ethan-1-one;1-(10-methylphenothiazin-2-yl)ethanone;MLS000549026;2-Acetyl-10-methylphenothiazine;EINECS 246-847-1;1-(10-methyl-2-phenothiazinyl)ethanone;SMR000114631;SR-01000683544;cid_91401;SCHEMBL1983443;CHEMBL1362864;BDBM56305;DTXSID60179968;CHEBI:121805;HMS2386C16;2-Acetyl-10-methyl-10H-phenothiazine;NCGC00247214-01;SR-01000683544-3;SR-01000683544-4;Q27210377

Suppliers and Price of 1-(10-Methyl-10H-phenothiazin-2-yl)ethan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of 1-(10-Methyl-10H-phenothiazin-2-yl)ethan-1-one

Chemical Property:

Vapor Pressure:4.39E-08mmHg at 25°C
Boiling Point:444.1°Cat760mmHg
Flash Point:222.4°C
PSA：45.61000
Density:1.226g/cm³
LogP:4.18670
XLogP3:3.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:255.07178521
Heavy Atom Count:18
Complexity:333

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)C1=CC2=C(C=C1)SC3=CC=CC=C3N2C

Technology Process of 1-(10-Methyl-10H-phenothiazin-2-yl)ethan-1-one

There total 9 articles about 1-(10-Methyl-10H-phenothiazin-2-yl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 6631-94-3
2-acetylphenothiazine

: 74-88-4
methyl iodide

: 25324-52-1
2-Acetyl-10-methylphenothiazine

Guidance literature:: 2-acetylphenothiazine; With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/acs.orglett.1c01213

Reference yield: 39.0%

: 25324-52-1
2-Acetyl-10-methylphenothiazine

Guidance literature:

Reference yield:

: 6631-94-3
2-acetylphenothiazine

: 25324-52-1
2-Acetyl-10-methylphenothiazine

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / BF₃*OEt₂ / benzene / 36 h / Heating

2: n-BuLi / hexane; tetrahydrofuran

3: tetrahydrofuran / -40 - 20 °C

4: HCl / tetrahydrofuran / 3 h

With hydrogenchloride; n-butyllithium; boron trifluoride diethyl etherate; In tetrahydrofuran; hexane; benzene;
DOI:10.1002/1099-0690(200109)2001:17<3255::AID-EJOC3255>3.0.CO;2-0