Furo[2,3-b]pyridine-2,5-dicarboxylic acid, diethyl ester

Base Information

Chemical Name:Furo[2,3-b]pyridine-2,5-dicarboxylic acid, diethyl ester
CAS No.:6562-80-7
Molecular Formula:C13H13NO5
Molecular Weight:263.25
Hs Code.:

Synonyms:

Suppliers and Price of Furo[2,3-b]pyridine-2,5-dicarboxylic acid, diethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of Furo[2,3-b]pyridine-2,5-dicarboxylic acid, diethyl ester

Chemical Property:

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of Furo[2,3-b]pyridine-2,5-dicarboxylic acid, diethyl ester

There total 11 articles about Furo[2,3-b]pyridine-2,5-dicarboxylic acid, diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 64-17-5
ethanol

: 170959-86-1
furo<2,3-b>pyridine-2,5-dicarboxylic acid 5-ethyl ester

: 6562-80-7
diethyl furo<2,3-b>pyridine-2,5-dicarbaxylate

Guidance literature:: With sulfuric acid; for 2h; Heating;
DOI:10.1002/jhet.5570320431

Reference yield:

: 6562-79-4
4-chloro-furo[2,3-b]pyridine-2,5-dicarboxylic acid diethyl ester

: 6562-80-7
diethyl furo<2,3-b>pyridine-2,5-dicarbaxylate

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol;

Reference yield:

: 611-13-2
2-furoic acid methyl ester

: 6562-80-7
diethyl furo<2,3-b>pyridine-2,5-dicarbaxylate

Guidance literature:: Multi-step reaction with 8 steps

1: 85 percent / 90percent HNO₃ / acetic anhydride; CH₂Cl₂ / 1.) Ac₂O,CH₂Cl₂, -5 deg C, 2h 2.) Ac₂O,CH₂Cl₂, room temp, 5h

2: 84 percent / H₂ / Pd,C / ethyl acetate / 2 h / 40 °C / 2068.6 Torr

3: 78 percent / ethyl acetate / 3.25 h / 120 °C / 1.) concentrated in vacuo at room temp to pot temp 90 deg C

4: 85 percent / 1.) Ph₂CH₂, heated to 240 deg C

5: 81 percent / POCl₃ / toluene / 1.5 h / 100 °C

6: LiOH*H₂O / tetrahydrofuran / Ambient temperature; overnight

7: 86 percent / ammonium formate / 2.) 5percent Pd on C / tetrahydrofuran; H₂O / 6 h / Ambient temperature

8: 67 percent / H₂SO₄ / 2 h / Heating

With lithium hydroxide; sulfuric acid; hydrogen; nitric acid; ammonium formate; trichlorophosphate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; acetic anhydride; ethyl acetate; toluene;
DOI:10.1002/jhet.5570320431