1,2,4-Pyrrolidinetricarboxylic acid, 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, 2-(1,1-dimethylethyl) 4-methyl 1-(phenylmethyl) ester, (2S,4R)-

Base Information

Chemical Name:1,2,4-Pyrrolidinetricarboxylic acid, 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, 2-(1,1-dimethylethyl) 4-methyl 1-(phenylmethyl) ester, (2S,4R)-
CAS No.:657412-46-9
Molecular Formula:C34H36N2O8
Molecular Weight:600.668
Hs Code.:

1,2,4-Pyrrolidinetricarboxylic acid,
4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, 2-(1,1-dimethylethyl)
4-methyl 1-(phenylmethyl) ester, (2S,4R)-

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Chemical Property of 1,2,4-Pyrrolidinetricarboxylic acid, 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, 2-(1,1-dimethylethyl) 4-methyl 1-(phenylmethyl) ester, (2S,4R)-

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Technology Process of 1,2,4-Pyrrolidinetricarboxylic acid, 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, 2-(1,1-dimethylethyl) 4-methyl 1-(phenylmethyl) ester, (2S,4R)-

There total 4 articles about 1,2,4-Pyrrolidinetricarboxylic acid, 4-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-, 2-(1,1-dimethylethyl) 4-methyl 1-(phenylmethyl) ester, (2S,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 900148-97-2
(2S,4R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2,4-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester

: 18107-18-1
diazomethyl-trimethyl-silane

: 657412-46-9
(2S,4R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2,4-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 4-methyl ester

Guidance literature:: In methanol; diethyl ether;
DOI:10.1021/ol060902q

Reference yield: 18.0%

: 657412-45-8
(3R,5S)-3-amino-1-((benzyloxy)carbonyl)-5-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid

: 657412-46-9
(2S,4R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2,4-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 4-methyl ester

Guidance literature:

Reference yield:

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 657412-46-9
(2S,4R)-4-(9H-fluoren-9-ylmethoxycarbonylamino)-pyrrolidine-1,2,4-tricarboxylic acid 1-benzyl ester 2-tert-butyl ester 4-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: TMS-Cl; diisopropylethylamine / CH₂Cl₂ / 1 h / Heating

1.2: 93 percent / CH₂Cl₂ / 0 - 20 °C

2.1: 85 percent / diethyl ether; methanol

With chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; dichloromethane;
DOI:10.1021/ol060902q