3,4-Dichloro-6-fluoroaniline

Base Information

• Chemical Name: 3,4-Dichloro-6-fluoroaniline
• CAS No.: 2729-36-4
• Molecular Formula: C6H4Cl2FN
• Molecular Weight: 180.009
• Hs Code.: 2921420090
• Mol file: 2729-36-4.mol

Synonyms:4,5-Dichlor-2-fluor-anilin;3,4-Dichloro-6-fluoroaniline;4,5-dichloro-2-fluoro-aniline;4,5-dichloro-2-fluorophenylamine;

Chemical Property of 3,4-Dichloro-6-fluoroaniline

Chemical Property:

• Vapor Pressure: 0.02mmHg at 25°C
• Boiling Point: 251.8°Cat760mmHg
• PKA: 1.51±0.10(Predicted)
• Flash Point: 106.1°C
• PSA: 26.02000
• Density: 1.502g/cm³
• LogP: 3.29590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

97% ^*data from raw suppliers

4,5-Dichloro-2-fluoroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3,4-Dichloro-6-fluoroaniline is used as pharmaceutical intermediates

Technology Process of 3,4-Dichloro-6-fluoroaniline

There total 5 articles about 3,4-Dichloro-6-fluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1,2-dichloro-4-fluoro-5-nitrobenzene (2339-78-8) → 4,5-dichloro-2-fluoro-phenylamine (2729-36-4)

Guidance literature:

1,2-dichloro-4-fluoro-5-nitrobenzene; With iron; acetic acid; In water; at 100 ℃; for 0.5h; Inert atmosphere;

With sodium hydrogencarbonate; In water; at 10 ℃; pH=8 - 9;

Reference yield:

1,2-dichloro-3-fluoro-5-nitrobenzene (35754-37-1) → 4,5-dichloro-2-fluoro-phenylamine (2729-36-4)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 85 ℃; for 1h;

Reference yield:

1,2-dichloro-4-fluoro-5-nitrobenzene (2339-78-8) + nickel (7440-02-0) → 4,5-dichloro-2-fluoro-phenylamine (2729-36-4)

Guidance literature:

With hydrazine hydrate; In EtOH-water; water ethanol;

upstream raw materials:

1,2-dichloro-4-fluoro-5-nitrobenzene

1,2-dichloro-4,5-dinitrobenzene

3,4-dichlorofluorobenzene

nickel

Downstream raw materials:

C₁₄H₁₁Cl₂FN₂O₃S

4-[(3,4-dichloro-6-fluorophenyl)amino]-7-fluoro-6-nitroquinazoline

2-bromo-N-(4,5-dichloro-2-fluoro-phenyl)-acetamide

6-amino-4-(4,5-dichloro-2-fluorophenylamino)quinazoline