2-([4-[([4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]carbamoyl)methyl]-5-sulfanylidene-4,5-dihydro-1,3,4-thiadiazol-2-yl]sulfanyl)butanedioic acid

Base Information

Chemical Name:2-([4-[([4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]carbamoyl)methyl]-5-sulfanylidene-4,5-dihydro-1,3,4-thiadiazol-2-yl]sulfanyl)butanedioic acid
CAS No.:1400741-85-6
Molecular Formula:C₂₂H₁₅Cl₂FN₆O₅S₃
Molecular Weight:629.501
Hs Code.:

2-([4-[([4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]carbamoyl)methyl]-5-sulfanylidene-4,5-dihydro-1,3,4-thiadiazol-2-yl]sulfanyl)butanedioic acid

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Chemical Property of 2-([4-[([4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]carbamoyl)methyl]-5-sulfanylidene-4,5-dihydro-1,3,4-thiadiazol-2-yl]sulfanyl)butanedioic acid

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Technology Process of 2-([4-[([4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]carbamoyl)methyl]-5-sulfanylidene-4,5-dihydro-1,3,4-thiadiazol-2-yl]sulfanyl)butanedioic acid

There total 7 articles about 2-([4-[([4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]carbamoyl)methyl]-5-sulfanylidene-4,5-dihydro-1,3,4-thiadiazol-2-yl]sulfanyl)butanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 1400741-92-5
N-[4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]-2-[5-[(2,5-dioxooxolan-3-yl)sulfanyl]-2-sulfanylidene-2,3-dihydro-1,3,4-thiadiazol-3-yl]acetamide

: 1400741-85-6
2-([4-[([4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]carbamoyl)methyl]-5-sulfanylidene-4,5-dihydro-1,3,4-thiadiazol-2-yl]sulfanyl)butanedioic acid

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; water; at 25 ℃; for 0.5h;

Reference yield:

: 2729-36-4
4,5-dichloro-2-fluoro-phenylamine

: 1400741-85-6
2-([4-[([4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]carbamoyl)methyl]-5-sulfanylidene-4,5-dihydro-1,3,4-thiadiazol-2-yl]sulfanyl)butanedioic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: isopropyl alcohol / 2 h / 90 °C / Inert atmosphere

2.1: acetic acid; iron / water / 1.5 h / 100 °C / Inert atmosphere

2.2: 10 °C / pH 8 - 9

3.1: tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

3.2: pH 8

4.1: hydrazine hydrate / tetrahydrofuran / 20 °C

5.1: pyridine / N,N-dimethyl-formamide / 1.5 h / 100 °C

5.2: pH 7

6.1: tetrahydrofuran / 4 h / 70 °C

7.1: hydrogenchloride / water; tetrahydrofuran / 0.5 h / 25 °C

With pyridine; hydrogenchloride; iron; hydrazine hydrate; acetic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 455922-78-8
4-[(3,4-dichloro-6-fluorophenyl)amino]-6-nitroquinazoline

: 1400741-85-6
2-([4-[([4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]carbamoyl)methyl]-5-sulfanylidene-4,5-dihydro-1,3,4-thiadiazol-2-yl]sulfanyl)butanedioic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; iron / water / 1.5 h / 100 °C / Inert atmosphere

1.2: 10 °C / pH 8 - 9

2.1: tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: pH 8

3.1: hydrazine hydrate / tetrahydrofuran / 20 °C

4.1: pyridine / N,N-dimethyl-formamide / 1.5 h / 100 °C

4.2: pH 7

5.1: tetrahydrofuran / 4 h / 70 °C

6.1: hydrogenchloride / water; tetrahydrofuran / 0.5 h / 25 °C

With pyridine; hydrogenchloride; iron; hydrazine hydrate; acetic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;