N-[4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]-2-[5-[(2,5-dioxooxolan-3-yl)sulfanyl]-2-sulfanylidene-2,3-dihydro-1,3,4-thiadiazol-3-yl]acetamide

Base Information

Chemical Name:N-[4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]-2-[5-[(2,5-dioxooxolan-3-yl)sulfanyl]-2-sulfanylidene-2,3-dihydro-1,3,4-thiadiazol-3-yl]acetamide
CAS No.:1400741-92-5
Molecular Formula:C₂₂H₁₃Cl₂FN₆O₄S₃
Molecular Weight:611.485
Hs Code.:

N-[4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]-2-[5-[(2,5-dioxooxolan-3-yl)sulfanyl]-2-sulfanylidene-2,3-dihydro-1,3,4-thiadiazol-3-yl]acetamide

Synonyms:N-[4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]-2-[5-[(2,5-dioxooxolan-3-yl)sulfanyl]-2-sulfanylidene-2,3-dihydro-1,3,4-thiadiazol-3-yl]acetamide

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Chemical Property of N-[4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]-2-[5-[(2,5-dioxooxolan-3-yl)sulfanyl]-2-sulfanylidene-2,3-dihydro-1,3,4-thiadiazol-3-yl]acetamide

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Technology Process of N-[4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]-2-[5-[(2,5-dioxooxolan-3-yl)sulfanyl]-2-sulfanylidene-2,3-dihydro-1,3,4-thiadiazol-3-yl]acetamide

There total 5 articles about N-[4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]-2-[5-[(2,5-dioxooxolan-3-yl)sulfanyl]-2-sulfanylidene-2,3-dihydro-1,3,4-thiadiazol-3-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 108-31-6
maleic anhydride

: 1400741-91-4
N-[4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]-2-(5-sulfanyl-2-sulfanylidene-2,3-dihydro-1,3,4-thiadiazol-3-yl)acetamide

: 1400741-92-5
N-[4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]-2-[5-[(2,5-dioxooxolan-3-yl)sulfanyl]-2-sulfanylidene-2,3-dihydro-1,3,4-thiadiazol-3-yl]acetamide

Guidance literature:: In tetrahydrofuran; at 70 ℃; for 4h;

Reference yield:

: 455922-78-8
4-[(3,4-dichloro-6-fluorophenyl)amino]-6-nitroquinazoline

: 1400741-92-5
N-[4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]-2-[5-[(2,5-dioxooxolan-3-yl)sulfanyl]-2-sulfanylidene-2,3-dihydro-1,3,4-thiadiazol-3-yl]acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid; iron / water / 1.5 h / 100 °C / Inert atmosphere

1.2: 10 °C / pH 8 - 9

2.1: tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2.2: pH 8

3.1: hydrazine hydrate / tetrahydrofuran / 20 °C

4.1: pyridine / N,N-dimethyl-formamide / 1.5 h / 100 °C

4.2: pH 7

5.1: tetrahydrofuran / 4 h / 70 °C

With pyridine; iron; hydrazine hydrate; acetic acid; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 455922-81-3
6-amino-4-(4,5-dichloro-2-fluorophenylamino)quinazoline

: 1400741-92-5
N-[4-[(4,5-dichloro-2-fluorophenyl)amino]quinazolin-6-yl]-2-[5-[(2,5-dioxooxolan-3-yl)sulfanyl]-2-sulfanylidene-2,3-dihydro-1,3,4-thiadiazol-3-yl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

1.2: pH 8

2.1: hydrazine hydrate / tetrahydrofuran / 20 °C

3.1: pyridine / N,N-dimethyl-formamide / 1.5 h / 100 °C

3.2: pH 7

4.1: tetrahydrofuran / 4 h / 70 °C

With pyridine; hydrazine hydrate; In tetrahydrofuran; N,N-dimethyl-formamide;