2-Cyclopenten-1-one, 3-chloro-2-[(1S)-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylpropyl]- 4-methyl-, (4S)-

Base Information

Chemical Name:2-Cyclopenten-1-one, 3-chloro-2-[(1S)-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylpropyl]- 4-methyl-, (4S)-
CAS No.:658080-27-4
Molecular Formula:C26H33ClO2Si
Molecular Weight:441.085
Hs Code.:

Synonyms:

Suppliers and Price of 2-Cyclopenten-1-one, 3-chloro-2-[(1S)-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylpropyl]- 4-methyl-, (4S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-Cyclopenten-1-one, 3-chloro-2-[(1S)-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylpropyl]- 4-methyl-, (4S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-Cyclopenten-1-one, 3-chloro-2-[(1S)-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylpropyl]- 4-methyl-, (4S)-

There total 12 articles about 2-Cyclopenten-1-one, 3-chloro-2-[(1S)-3-[[(1,1-dimethylethyl)diphenylsilyl]oxy]-1-methylpropyl]- 4-methyl-, (4S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 658080-32-1
(S)-2-[(S)-3-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-propyl]-4-methyl-3-phenylsulfanyl-cyclopentanone

: 658080-27-4
(S)-2-[(S)-3-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-propyl]-3-chloro-4-methyl-cyclopent-2-enone

Guidance literature:: With trichloroisocyanuric acid; In diethyl ether; benzene; at 0 ℃; for 21h;
DOI:10.1002/anie.200351750

Reference yield:

: (S)-3-Methyl-4-trityloxy-butyronitrile

: 658080-27-4
(S)-2-[(S)-3-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-propyl]-3-chloro-4-methyl-cyclopent-2-enone

Guidance literature:: Multi-step reaction with 7 steps

1.1: diisobutyl aluminium hydride / CH₂Cl₂ / 0.5 h / -78 °C

2.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

2.2: tetrahydrofuran / 1.5 h / -78 °C

3.1: HCOOH / diethyl ether / 5.5 h / 20 °C

3.2: NH₃ / H₂O; methanol / 1.5 h / 20 °C

4.1: 67 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

5.1: SmI₂ / tetrahydrofuran / 1 h / 20 °C

5.2: 73 percent / Al₂O₃

6.1: 71 percent / NEt₃ / tetrahydrofuran / 7 h / 20 °C

7.1: 79 percent / trichloroisocyanuric acid / benzene; diethyl ether / 21 h / 0 °C

With n-butyllithium; formic acid; samarium diiodide; trichloroisocyanuric acid; diisobutylaluminium hydride; Dess-Martin periodane; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; benzene; 6.1: Michael addition;
DOI:10.1002/anie.200351750

Reference yield:

: 658080-23-0
(S)-3-methyl-4-(trityloxy)butanal

: 658080-27-4
(S)-2-[(S)-3-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-propyl]-3-chloro-4-methyl-cyclopent-2-enone

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

1.2: tetrahydrofuran / 1.5 h / -78 °C

2.1: HCOOH / diethyl ether / 5.5 h / 20 °C

2.2: NH₃ / H₂O; methanol / 1.5 h / 20 °C

3.1: 67 percent / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

4.1: SmI₂ / tetrahydrofuran / 1 h / 20 °C

4.2: 73 percent / Al₂O₃

5.1: 71 percent / NEt₃ / tetrahydrofuran / 7 h / 20 °C

6.1: 79 percent / trichloroisocyanuric acid / benzene; diethyl ether / 21 h / 0 °C

With n-butyllithium; formic acid; samarium diiodide; trichloroisocyanuric acid; Dess-Martin periodane; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; benzene; 5.1: Michael addition;
DOI:10.1002/anie.200351750