Technology Process of Butanal, 3-methyl-4-(triphenylmethoxy)-, (3S)-
There total 3 articles about Butanal, 3-methyl-4-(triphenylmethoxy)-, (3S)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: dimethylsulfoxide / 21 h / 60 °C
2: diisobutyl aluminium hydride / CH2Cl2 / 0.5 h / -78 °C
With
diisobutylaluminium hydride;
In
dichloromethane; dimethyl sulfoxide;
DOI:10.1002/anie.200351750
- Guidance literature:
-
Multi-step reaction with 3 steps
1: pyridine / 20.5 h / 20 °C
2: dimethylsulfoxide / 21 h / 60 °C
3: diisobutyl aluminium hydride / CH2Cl2 / 0.5 h / -78 °C
With
pyridine; diisobutylaluminium hydride;
In
dichloromethane; dimethyl sulfoxide;
DOI:10.1002/anie.200351750
- Guidance literature:
-
With
(acetylacetonato)dicarbonylrhodium (l); (S,S)-YanPhos; hydrogen;
In
toluene;
at 80 ℃;
for 48h;
under 3750.38 Torr;
Overall yield = 95 %; enantioselective reaction;
Autoclave;
DOI:10.1021/jacs.8b00275
