Benzamide, 2,4-difluoro-N-methoxy-5-[[5-(1-methylethyl)-6-[5-[(methylsulfonyl)methyl] -1,3,4-oxadiazol-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]-

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Chemical Name:Benzamide, 2,4-difluoro-N-methoxy-5-[[5-(1-methylethyl)-6-[5-[(methylsulfonyl)methyl] -1,3,4-oxadiazol-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]-
CAS No.:658085-06-4
Molecular Formula:C21H21F2N7O5S
Molecular Weight:521.504
Hs Code.:

Benzamide,
2,4-difluoro-N-methoxy-5-[[5-(1-methylethyl)-6-[5-[(methylsulfonyl)methyl]
-1,3,4-oxadiazol-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]-

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Chemical Property of Benzamide, 2,4-difluoro-N-methoxy-5-[[5-(1-methylethyl)-6-[5-[(methylsulfonyl)methyl] -1,3,4-oxadiazol-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]-

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Technology Process of Benzamide, 2,4-difluoro-N-methoxy-5-[[5-(1-methylethyl)-6-[5-[(methylsulfonyl)methyl] -1,3,4-oxadiazol-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]-

There total 8 articles about Benzamide, 2,4-difluoro-N-methoxy-5-[[5-(1-methylethyl)-6-[5-[(methylsulfonyl)methyl] -1,3,4-oxadiazol-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 658085-51-9
5-amino-2,4-difluoro-N-methoxybenzamide

: 5-(1-methylethyl)-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-6-carboxylic acid (1-ethoxy-2-methanesulfonylethylidene)hydrazide

: 658085-06-4
2,4-difluoro-N-methoxy-5-[[5-(1-methylethyl)-6-[5-[(methylsulfonyl)methyl]-1,3,4-oxadiazol-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]benzamide

Guidance literature:: 5-(1-methylethyl)-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazin-6-carboxylic acid (1-ethoxy-2-methanesulfonylethylidene)hydrazide; With trichlorophosphate; at 80 - 120 ℃; for 1.75h;

5-amino-2,4-difluoro-N-methoxybenzamide; In acetonitrile; for 16h;

Reference yield:

: 639858-45-0
5-amino-2,4-difluorobenzoic acid

: 658085-06-4
2,4-difluoro-N-methoxy-5-[[5-(1-methylethyl)-6-[5-[(methylsulfonyl)methyl]-1,3,4-oxadiazol-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2.98 g / EDCI; HOBt; diisopropylethylamine / tetrahydrofuran / 6 h / 20 °C

2: dimethylformamide / 6 h / 50 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm0501275

Reference yield:

: 658085-53-1
5-isopropyl-4-oxo-3,4-dihydropyrrolo[2,1-f][1,2,4]triazine-6-carbohydrazide

: 658085-06-4
2,4-difluoro-N-methoxy-5-[[5-(1-methylethyl)-6-[5-[(methylsulfonyl)methyl]-1,3,4-oxadiazol-2-yl]pyrrolo[2,1-f][1,2,4]triazin-4-yl]amino]benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: POCl₃ / 4 h / 100 - 120 °C

2: dimethylformamide / 6 h / 50 °C

With trichlorophosphate; In N,N-dimethyl-formamide;
DOI:10.1021/jm0501275