Benzyloxycarbonylaminoacetyl chloride

Base Information

• Chemical Name: Benzyloxycarbonylaminoacetyl chloride
• CAS No.: 15050-24-5
• Molecular Formula: C10H10ClNO3
• Molecular Weight: 227.647
• DSSTox Substance ID: DTXSID00481931
• Wikidata: Q82317642
• Mol file: 15050-24-5.mol

Synonyms:Benzyloxycarbonylaminoacetyl chloride;15050-24-5;Benzyl (2-chloro-2-oxoethyl)carbamate;BENZYL N-(2-CHLORO-2-OXOETHYL)CARBAMATE;N-[(benzyloxy)carbonyl]glycyl chloride;Cbz-Gly-Cl;N-Carbobenzoxy-glycyl-chlorid;SCHEMBL3253354;DTXSID00481931;N-benzyloxycarbonylglycyl chloride;HJJNNRNPEWJNSR-UHFFFAOYSA-N;N-benzyloxycarbonylglycine chloride;MFCD20483403;N-benzyloxycarbonylaminoacetyl chloride

Chemical Property of Benzyloxycarbonylaminoacetyl chloride

Chemical Property:

• PSA: 58.89000
• LogP: 1.88260
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 227.0349209
• Heavy Atom Count: 15
• Complexity: 227

Purity/Quality:

99%, ^*data from raw suppliers

Benzyloxycarbonylaminoacetyl chloride 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)COC(=O)NCC(=O)Cl

Technology Process of Benzyloxycarbonylaminoacetyl chloride

There total 6 articles about Benzyloxycarbonylaminoacetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(Benzyloxycarbonyl)glycine (1138-80-3) → N-(benzyloxycarbonyl)glycyl chloride (15050-24-5)

Guidance literature:

With diethyl ether; phosphorus pentachloride; unter Kuehlung;

DOI:10.1002/hlca.19480310215

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → N-(benzyloxycarbonyl)glycyl chloride (15050-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1: aqueous NaOH / unter Kuehlung

2: diethyl ether; PCl₅ / unter Kuehlung

With sodium hydroxide; diethyl ether; phosphorus pentachloride;

Reference yield:

benzyl alcohol (100-51-6,185532-71-2) → N-(benzyloxycarbonyl)glycyl chloride (15050-24-5)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / anfangs unter Kuehlung

2: aqueous NaOH / unter Kuehlung

3: diethyl ether; PCl₅ / unter Kuehlung

With sodium hydroxide; diethyl ether; phosphorus pentachloride; toluene;

upstream raw materials:

N-(Benzyloxycarbonyl)glycine

diethyl ether

phosphorus pentachloride

chloroform

Downstream raw materials:

[2-(2-Benzyloxycarbonylamino-acetylamino)-acetylamino]-acetic acid

N-benzyloxycarbonyl-glycine-(2,4-dinitro-phenyl ester)

Z-Gly-Sar-OH

N-(N-benzyloxycarbonyl-glycyl)-β-alanine ethyl ester