1-Aminoindane Hydrochloride

Base Information

• Chemical Name: 1-Aminoindane Hydrochloride
• CAS No.: 70146-15-5
• Molecular Formula: C9H11N^.HCl
• Molecular Weight: 169.654
• Hs Code.: 2921499090
• NSC Number: 186227
• UNII: 9QG7BG5MQU
• DSSTox Substance ID: DTXSID80383207
• Mol file: 70146-15-5.mol

Synonyms:1-Aminoindane Hydrochloride;70146-15-5;2,3-dihydro-1H-inden-1-amine Hydrochloride;1-Aminoindan Hydrochloride;1-AMINOINDANE HCL;2,3-dihydro-1H-inden-1-amine;hydrochloride;(S)-1-Aminoindane Hydrochloride;9QG7BG5MQU;1-Indanamine, hydrochloride;2,3-Dihydro-1H-inden-1-amine, HCl;1H-Inden-1-amine, 2,3-dihydro-, hydrochloride;(R)-1-Aminoindane-d3Hydrochloride;MFCD00054294;NSC-186227;1H-Inden-1-amine, 2,3-dihydro-, hydrochloride (1:1);Indan-1-amine hydrochloride;indanamin hydrochloride;MFCD16661198;aminoindan hydrochloride;amino indane hydrochloride;UNII-9QG7BG5MQU;SCHEMBL2033301;(S)-(+)-1-Aminoindan HCl;DTXSID80383207;RHAAGWRBIVCBSY-UHFFFAOYSA-N;BCP04726;BCP15726;CS-D1386;NSC186227;AKOS015844420;AC-4420;NSC 186227;PB49163;SB44445;2-Trifluoromethyl-4-fluorobenzylchloride;DS-13393;SY004234;SY028017;SY030463;2,3-dihydro-1h-inden-1-aminehydrochloride;AM20040231;FT-0652621;FT-0659752;FT-0660461;EN300-41695;2,3-Dihydro-1H-inden-1-ylamine hydrochloride;W-203569

Chemical Property of 1-Aminoindane Hydrochloride

Chemical Property:

• Vapor Pressure: 0.0886mmHg at 25°C
• Melting Point: 206-210 °C
• Boiling Point: 225 °C at 760 mmHg
• Flash Point: 94.4 °C
• PSA: 26.02000
• Density: 1.056 g/cm3
• LogP: 3.13490
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: DMSO (Sparingly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 169.0658271
• Heavy Atom Count: 11
• Complexity: 122

Purity/Quality:

99%Min. ^*data from raw suppliers

1-AminoindaneHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CC2=CC=CC=C2C1N.Cl
• Uses: 1-Aminoindane Hydrochloride was found to reduce appetite and motor activity in rats.

Technology Process of 1-Aminoindane Hydrochloride

There total 6 articles about 1-Aminoindane Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-azido-2,3-dihydro-1H-indene (144192-67-6) → 2,3-dihydro-1H-inden-1-amine hydrochloride (70146-15-5,10305-73-4)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; chloroform; at 25 ℃; for 20h;

DOI:10.3109/14756366.2012.750311

Reference yield: 62.0%

INDANE (496-11-7) → 2,3-dihydro-1H-inden-1-amine hydrochloride (70146-15-5,10305-73-4)

Guidance literature:

INDANE; With Benzophenone imine; copper(l) iodide; 1,10-Phenanthroline; di-tert-butyl peroxide; In chlorobenzene; at 90 ℃; for 48h; Inert atmosphere; Sealed tube;

With hydrogenchloride; In methanol; water; chlorobenzene; at 40 ℃; for 15h; regioselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.8b03505

Reference yield:

2,3-dihydro-1H-inden-1-amine (34698-41-4) → 2,3-dihydro-1H-inden-1-amine hydrochloride (70146-15-5,10305-73-4)

Guidance literature:

With hydrogenchloride; In ethyl acetate;

DOI:10.1021/jacs.0c00212

upstream raw materials:

1-azido-2,3-dihydro-1H-indene

inden-1-one

1-Indanol

INDANE

Downstream raw materials:

1-indene

2,3-dihydro-1H-inden-1-amine

N-(2,3-dihydro-1H-inden-1-yl)acetamide

Refernces

• 1、 An, Qing,Chen, Yuegang,Liu, Weimin,Pan, Hui,Wang, Xin,Wang, Ziyu,Zhang, Kaining,Zuo, Zhiwei. "Cerium-Catalyzed C-H Functionalizations of Alkanes Utilizing Alcohols as Hydrogen Atom Transfer Agents". supporting information. p. 6216 - 6226. Retrieved 2020/04/27.
• 2、 Lenstra, Danny C.,Lenting, Peter E.,Mecinovi?, Jasmin. "Sustainable organophosphorus-catalysed Staudinger reduction". supporting information. p. 4418 - 4422. Retrieved 2018/10/17.