Chemical Property of PELITINIB
Chemical Property:
- Appearance/Colour:off-white solid
- Vapor Pressure:4.64E-17mmHg at 25°C
- Melting Point:173-178°C
- Refractive Index:1.644
- Boiling Point:655.5 °C at 760 mmHg
- PKA:12.23±0.43(Predicted)
- Flash Point:350.2 °C
- PSA：90.28000
- Density:1.34 g/cm3
- LogP:5.24358
- Storage Temp.:-20°C Freezer
- Solubility.:DMSO: soluble5mg/mL, clear (warmed)
- XLogP3:4.5
- Hydrogen Bond Donor Count:2
- Hydrogen Bond Acceptor Count:7
- Rotatable Bond Count:8
- Exact Mass:467.1524308
- Heavy Atom Count:33
- Complexity:729
- Purity/Quality:
-
99%, *data from raw suppliers
Pelitinib *data from reagent suppliers
Safty Information:
- Pictogram(s):
T
- Hazard Codes:T
- Statements:
25
- Safety Statements:
45
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)F)Cl)C#N)NC(=O)C=CCN(C)C
- Isomeric SMILES:CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)F)Cl)C#N)NC(=O)/C=C/CN(C)C
- Recent ClinicalTrials:CCI-779 and EKB-569 in Treating Patients With Advanced Solid Tumors
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Description
Pelitinib is a cyanoquinoline that irreversibly inhibits the EGFR receptor tyrosine kinase (IC50 = 39 nM). It inhibits HER2 with a much weaker potency (IC50 = 1.2 μM). By disrupting Akt and MAPK pathways, pelitinib can induce apoptosis and suppress the growth of tumor cell lines, displaying particularly strong efficacy against hepatocellular carcinoma cells (IC50s = ~2 μM).
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Uses
Pelitinib is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. An EGFR inhibitor Labelled Pelitinib (P218702). A tyrosine kinase inhibitor; it is used to prepare formulation for treating primary or secondary cancer.
