4,5-DIHYDRO-2-(2-IODOPHENYL)-4,4-DIMETHYLOXAZOLE

Base Information

• Chemical Name: 4,5-DIHYDRO-2-(2-IODOPHENYL)-4,4-DIMETHYLOXAZOLE
• CAS No.: 66195-42-4
• Molecular Formula: C11H12INO
• Molecular Weight: 301.127
• Hs Code.: 2934999090
• Mol file: 66195-42-4.mol

Synonyms:2-(2-Iodphenyl)-4,4-dimethyl-2-oxazolin;2-(2-iodophenyl)-4,4-dimethyl-4,5-dihydrooxazole;2-(2-iodophenyl)-4,4-dimethyl-2-oxazoline;2-(2-iodo-phenyl)-4,4-dimethyl-4,5-dihydro-oxazole;4,4-dimethyl-2-(2-iodophenyl)-oxazoline;

Chemical Property of 4,5-DIHYDRO-2-(2-IODOPHENYL)-4,4-DIMETHYLOXAZOLE

Chemical Property:

• PSA: 21.59000
• LogP: 2.28220

Purity/Quality:

2-(2-IODOPHENYL)-4,4-DIMETHYL-4,5-DIHYDRO-1,3-OXAZOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5-DIHYDRO-2-(2-IODOPHENYL)-4,4-DIMETHYLOXAZOLE

There total 7 articles about 4,5-DIHYDRO-2-(2-IODOPHENYL)-4,4-DIMETHYLOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4,5-dihydro-4,4-dimethyl-2-phenoxazole (19312-06-2) + iodine (7553-56-2,12190-71-5,8031-47-8) → 2-(2-iodophenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole (66195-42-4)

Guidance literature:

4,5-dihydro-4,4-dimethyl-2-phenoxazole; With 2C₁₅H₂₆NSi^(1-)*C₄H₉^(1-)*Na⁽¹⁺⁾*Mg⁽²⁺⁾; In methyl cyclohexane; at 101 ℃;

iodine; In tetrahydrofuran;

DOI:10.1002/chem.201602683

Reference yield: 91.0%

4,5-dihydro-4,4-dimethyl-2-phenoxazole (19312-06-2) → 2-(2-iodophenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole (66195-42-4)

Guidance literature:

4,5-dihydro-4,4-dimethyl-2-phenoxazole; With di-sec-butylmagnesium; In toluene; at 25 ℃; for 1h;

With iodine; regioselective reaction;

DOI:10.1039/d1sc01777b

Reference yield: 68.0%

N-(1-hydroxy-2-methylprop-2-yl)-2-iodobenzamide (66195-41-3) → 2-(2-iodophenyl)-4,4-dimethyl-4,5-dihydro-1,3-oxazole (66195-42-4)

Guidance literature:

N-(1-hydroxy-2-methylprop-2-yl)-2-iodobenzamide; With dmap; triethylamine; p-toluenesulfonyl chloride; In dichloromethane; at 0 - 20 ℃;

With water; In dichloromethane; for 1h; Reflux;

DOI:10.1016/j.tet.2010.04.125

upstream raw materials:

4,5-dihydro-4,4-dimethyl-2-phenoxazole

N-(1-hydroxy-2-methylprop-2-yl)-2-iodobenzamide

2-Iodobenzoyl chloride

2-Iodobenzoic acid

Downstream raw materials:

4,4-dimethyl-2-(2-(thiophene-2-yl)phenyl)-4,5-dihydrooxazole

2-<(5-chloro-2-nitrophenyl)seleno>benzoic acid

2-selenocyanato-benzoic acid

2-([1,1'-biphenyl]-2-yl)-4,4-dimethyl-4,5-dihydrooxazole

Refernces

• 1、 G?bel, Dominik,Clamor, Nils,Lork, Enno,Nachtsheim, Boris J.. "Aerobic C(sp2)-H Hydroxylations of 2-Aryloxazolines: Fast Access to Excited-State Intramolecular Proton Transfer (ESIPT)-Based Luminophores". supporting information. p. 5373 - 5377. Retrieved 2019/06/07.
• 2、 Batista, Joo H. C.,Santos, Fernanda M. Dos,Bozzini, Leandro A.,Vessecchi, Ricardo,Oliveira, Alfredo R. M.,Clososki, Giuliano C.. "Directed functionalization of halophenyl-2-oxazolines with TMPMgCl?LiCl". supporting information. p. 967 - 977. Retrieved 2015/02/19.