N-(1-hydroxy-2-methylpropan-2-yl)-2-iodobenzamide

Base Information

Chemical Name:N-(1-hydroxy-2-methylpropan-2-yl)-2-iodobenzamide
CAS No.:66195-41-3
Molecular Formula:C11H14INO2
Molecular Weight:319.142
Hs Code.:
DSSTox Substance ID:DTXSID601242827

Synonyms:66195-41-3;DTXSID601242827;N-(2-Hydroxy-1,1-dimethylethyl)-2-iodobenzamide

Suppliers and Price of N-(1-hydroxy-2-methylpropan-2-yl)-2-iodobenzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(1-hydroxy-2-methylpropan-2-yl)-2-iodobenzamide

Chemical Property:

XLogP3:1.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:3
Exact Mass:319.00693
Heavy Atom Count:15
Complexity:231

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(CO)NC(=O)C1=CC=CC=C1I

Technology Process of N-(1-hydroxy-2-methylpropan-2-yl)-2-iodobenzamide

There total 3 articles about N-(1-hydroxy-2-methylpropan-2-yl)-2-iodobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 609-67-6
2-Iodobenzoyl chloride

: 124-68-5
2-Amino-2-methyl-1-propanol

: 66195-41-3
N-(1-hydroxy-2-methylprop-2-yl)-2-iodobenzamide

Guidance literature:: With sodium hydrogencarbonate; In 1,4-dioxane; water; at 20 ℃; for 3.08333h;
DOI:10.1016/j.tet.2010.04.125

Reference yield:

: 88-67-5
2-Iodobenzoic acid

: 66195-41-3
N-(1-hydroxy-2-methylprop-2-yl)-2-iodobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 6 h / 60 °C / Inert atmosphere; Schlenk technique

2: dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

With thionyl chloride; In dichloromethane;
DOI:10.1021/acs.orglett.9b01350