2,3-Diamino-4,5-dichloropyridine

Base Information

• Chemical Name: 2,3-Diamino-4,5-dichloropyridine
• CAS No.: 662116-66-7
• Molecular Formula: C5H5Cl2N3
• Molecular Weight: 178.021
• Hs Code.: 2933399090
• Mol file: 662116-66-7.mol

Synonyms:4,5-dichloropyridine-2,3-diamine;

Chemical Property of 2,3-Diamino-4,5-dichloropyridine

Chemical Property:

• Boiling Point: 344.2±37.0 °C(Predicted)
• PKA: 3.52±0.50(Predicted)
• PSA: 64.93000
• Density: 1.602
• LogP: 2.71520
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4,5-dichloropyridine-2,3-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,3-Diamino-4,5-dichloropyridine

There total 5 articles about 2,3-Diamino-4,5-dichloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4,5-dichloro-3-nitropyridin-2-ylamine (662116-67-8) → 2,3-diamino-4,5-dichloropyridine (662116-66-7)

Guidance literature:

With hydrogenchloride; iron; In methanol; ethanol; water; at 80 ℃; for 1.5h;

Reference yield:

2-Amino-4-chloropyridine (19798-80-2) → 2,3-diamino-4,5-dichloropyridine (662116-66-7)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 12 h / 0 - 20 °C

2: N-chloro-succinimide / acetonitrile / 2 h / 70 °C

3: sulfuric acid; nitric acid / water / 2.5 h / 20 °C

4: ethanol; zinc; calcium chloride / 1 h / 100 °C

With pyridine; N-chloro-succinimide; ethanol; sulfuric acid; nitric acid; calcium chloride; zinc; In water; acetonitrile;

Reference yield:

4,5-dichloro-2-aminopyridine (188577-68-6) → 2,3-diamino-4,5-dichloropyridine (662116-66-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid; nitric acid / -10 - 55 °C

2: iron; ammonium chloride; water / methanol / 20 °C

With sulfuric acid; water; nitric acid; iron; ammonium chloride; In methanol;

DOI:10.1016/j.bmcl.2015.11.031

upstream raw materials:

4,5-dichloro-3-nitropyridin-2-ylamine

2-Amino-4-chloropyridine

4-chloro-2-trimethylacetamidopyridine

N-(4,5-dichloropyridin-2-yl)-2,2-dimethylpropanamide

Downstream raw materials:

6,7-dichloro-2-[4-(4-morpholinyl)phenyl]-1H-imidazo[4,5-b]pyridine

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