662116-67-8

Basic information

• Product Name: 2-Amino-4,5-dichloro-3-nitropyridine
• Synonyms: 2-Amino-4,5-dichloro-3-nitropyridine;2-AMino-4,5-dichloro-3-ni...;4,5-dichloro-3-nitropyridin-2-aMine
• CAS NO: 662116-67-8
• Molecular Formula: C₅H₃Cl₂N₃O₂
• Molecular Weight: 208.00222
• EINECS: 604-604-1
• Mol File: 662116-67-8.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 337.2±37.0 °C(Predicted)
• Appearance: /
• Density: 1.723±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: -0.86±0.50(Predicted)
• CAS DataBase Reference: 2-Amino-4,5-dichloro-3-nitropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-4,5-dichloro-3-nitropyridine(662116-67-8)
• EPA Substance Registry System: 2-Amino-4,5-dichloro-3-nitropyridine(662116-67-8)

Safety Data

• Hazardous Substances Data: 662116-67-8(Hazardous Substances Data)

Usage

General Description

2-Amino-4,5-dichloro-3-nitropyridine is a chemical compound with the formula C5H3Cl2N3O2. It belongs to the organic class of compounds known as dichlorobenzenes, which are compounds that contain a benzene with exactly two chlorine atoms attached. This colorless solid is a significant reagent in chemical synthesis, used primarily as a building block to produce other chemicals, including pesticides, pharmaceuticals, and dyes. As with many nitro compounds, 2-Amino-4,5-dichloro-3-nitropyridine can potentially be explosive, particularly when mixed with other reactive chemicals or heated. Hence, it must be handled with care. Toxicity information is not widely available, so appropriate safety precautions should be taken during its use.

Upstream product

• 188577-70-0 4-chloro-2-trimethylacetamidopyridine 
• 6980-08-1 4-chloro-3-nitro-2-pyridinamine 
• 19798-80-2 2-Amino-4-chloropyridine 
• 188577-68-6 4,5-dichloro-2-aminopyridine 
• 188577-71-1 N-(4,5-dichloropyridin-2-yl)-2,2-dimethylpropanamide 

Downstream Products

• 942948-56-3 5-chloro-4-(4-(4-chlorobenzyl)piperazin-1-yl)-3-nitropyridin-2-amine 
• 942948-16-5 5-chloro-4-(4-(2-chloro-6-fluorobenzyl)piperazin-1-yl)-3-nitropyridin-2-amine 
• 942950-75-6 5-chloro-3-nitro-4-(4-phenethylpiperazin-1-yl)pyridin-2-amine 
• 942949-12-4 2-(4-(2-amino-5-chloro-3-nitropyridin-4-yl)piperazin-1-yl)-N-(3-methylisoxazol-5-yl)acetamide 
• 942948-06-3 5-chloro-3-nitro-4-[4-(2-phenoxy-ethyl)-piperazin-1-yl]-pyridin-2-ylamine 
• 1402709-93-6 CCT₂₄₁₇₃₆ 
• 1446244-53-6 N-(3-((2,3-diamino-5-chloropyridin-4-yl)oxy)phenyl)acrylamide 
• 1446244-32-1 N-(3-(6-chloro-2-(4-(4-methylpiperazin-1-yl)phenyl)-3H-imidazo[4,5-b]pyridin-7-yloxy)phenyl)acrylamide 
• 1446244-52-5 N-(3-((2-amino-5-chloro-3-nitropyridin-4-yl)oxy)phenyl)acrylamide 
• 1095381-18-2 tert-butyl 4-(4-(6-chloro-7-(4-((6-(trifluoromethyl)pyridin-3-yl)methyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)piperazine-1-carboxylate 
• 1095381-83-1 tert-butyl 4-(4-(6-chloro-7-(4-(2-oxo-2-(thiazol-2-ylamino)ethyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)phenyl)piperazine-1-carboxylate 
• 1095380-83-8 tert-butyl 4-(4-(6-chloro-7-(4-(cyclobutylmethyl)piperazin-1-yl)-3H-imidazo[4,5-b]pyridin-2-yl)benzyl)piperazine-1-carboxylate 

Relevant articles and documents

Heteroaryl compound and application thereof

The invention discloses a heteroaryl compound and application thereof, and provides a heteroaryl compound as shown in a formula I, a tautomer, a stereoisomer or a pharmaceutically acceptable salt thereof. The compound has good tumor inhibition activity, e

Substituted heteroaryl compound and composition and application thereof

The invention provides a substituted heteroaryl compound and a pharmaceutical composition and application thereof. The compound is a compound as shown in formula (I) or the stereisomer, tautomer, nitric oxide, solvate, metabolite, pharmaceutically acceptable salt or prodrug of the compound as shown in formula (I). The pharmaceutical composition containing the compound can regulate the activity ofprotein kinase and especially the activity of Aurora kinase and JAK kinase and is used for preventing, treating and relieving diseases or disorder mediated by protein kinase and especially JAK kinase.

2-PHENYLIMIDAZO[4,5-B]PYRIDIN-7-AMINE DERIVATES USEFUL AS INHIBITORS OF MAMMALIAN TYROSINE KINASE ROR1 ACTIVITY

Compound of formula (I′) or (I′′) or a pharmaceutically acceptable salt thereof. The compound is an inhibitor of mammalian kinase enzyme activity, including ROR1 tyrosine kinase activity and may be used in the treatment of disorders associated with such activity.