cyclobutane-1,3-dicarboxylic acid

Base Information

• Chemical Name: cyclobutane-1,3-dicarboxylic acid
• CAS No.: 2398-16-5
• Molecular Formula: C₆H₈O₄
• Molecular Weight: 144.127
• Hs Code.: 2917209090
• Mol file: 2398-16-5.mol

Synonyms:1,3-cis-Cyclobutanedicarboxylicacid; cis-1,3-Cyclobutanedicarboxylic acid

Chemical Property of cyclobutane-1,3-dicarboxylic acid

Chemical Property:

• Vapor Pressure: 0.00585mmHg at 25°C
• Melting Point: 135-136oC
• Refractive Index: 1.5800 (estimate)
• Boiling Point: 253°Cat760mmHg
• PKA: pK1:4.04 ;pK2:5.31 (25°C)
• Flash Point: 121.1°C
• PSA: 74.60000
• Density: 1.509g/cm³
• LogP: 0.18180
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

cis-Cyclobutane-1,3-dicarboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of cyclobutane-1,3-dicarboxylic acid

There total 12 articles about cyclobutane-1,3-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

cis-1,3-bis(hydroxymethyl)cyclobutane (2453-47-6) → cis-1,3-cyclobutane dicarboxylic acid (2398-16-5)

Guidance literature:

With nitric acid; at 120 ℃; for 3h;

Reference yield: 19.0%

1,1,3,3-cyclobutanetetracarboxylic acid (7371-69-9) → cis-1,3-cyclobutane dicarboxylic acid (2398-16-5) + trans-cyclobutane-1,3-dicarboxylic acid (7439-33-0)

Guidance literature:

Reference yield:

7‐phenyl‐6,8‐dioxaspiro[3.5]nonane‐2,2‐dicarboxylic acid (77614-64-3) → cis-1,3-cyclobutane dicarboxylic acid (2398-16-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / HNO₃

2: 185 °C / 20 - 60 Torr

With nitric acid;

upstream raw materials:

Dimethoxymethane

tetraethyl 1,1,3,3-propanetetracarboxylate

(E)-3-Ureido-but-2-enoic acid ethyl ester

2-chloro-propanoic acid, ethyl ester

Downstream raw materials:

cis-cyclobutane-dicarboxylic acid-(1.3)-dimethyl ester

cis-1,3-Cyclobutandicarbonsaeureanhydrid

cis-1,3-bis(hydroxymethyl)cyclobutane ditosylate

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