Cyclobutane-1α,3β-dicarboxylic acid

Base Information

• Chemical Name: Cyclobutane-1α,3β-dicarboxylic acid
• CAS No.: 7439-33-0
• Molecular Formula: C6H8O4
• Molecular Weight: 144.12500
• Mol file: 7439-33-0.mol

Synonyms:1,3-Cyclobutanedicarboxylic acid, trans-;trans-1,3-Cyclobutanedicarboxylic acid;

Chemical Property of Cyclobutane-1α,3β-dicarboxylic acid

Chemical Property:

• Melting Point: 171°C
• Refractive Index: 1.5800 (estimate)
• Boiling Point: 222.71°C (rough estimate)
• PKA: 4.17±0.40(Predicted)
• PSA: 74.60000
• Density: 1.3217 (rough estimate)
• LogP: 0.18180
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

95%+ ^*data from raw suppliers

trans-Cyclobutane-1,3-dicarboxylic acid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cyclobutane-1α,3β-dicarboxylic acid

There total 4 articles about Cyclobutane-1α,3β-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

1,1,3,3-cyclobutanetetracarboxylic acid (7371-69-9) → cis-1,3-cyclobutane dicarboxylic acid (2398-16-5) + trans-cyclobutane-1,3-dicarboxylic acid (7439-33-0)

Guidance literature:

Reference yield:

7‐phenyl‐6,8‐dioxaspiro[3.5]nonane‐2,2‐dicarboxylic acid (77614-64-3) → trans-cyclobutane-1,3-dicarboxylic acid (7439-33-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 94 percent / HNO₃

2: 185 °C / 20 - 60 Torr

With nitric acid;

Reference yield:

2,2‐diethyl 7‐phenyl‐6,8‐dioxaspiro[3.5]nonane‐2,2‐dicarboxylate (142733-60-6) → trans-cyclobutane-1,3-dicarboxylic acid (7439-33-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 92 percent / KOH

2: 94 percent / HNO₃

3: 185 °C / 20 - 60 Torr

With potassium hydroxide; nitric acid;

upstream raw materials:

1,1,3,3-cyclobutanetetracarboxylic acid

7‐phenyl‐6,8‐dioxaspiro[3.5]nonane‐2,2‐dicarboxylic acid

2,2‐diethyl 7‐phenyl‐6,8‐dioxaspiro[3.5]nonane‐2,2‐dicarboxylate

Downstream raw materials:

trans-1,3-Cyclobutan-dicarbonsaeure-dimethylester

Refernces

• 1、 Schwarz, Wolfgang,Trautmann, Walter,Musso, Hans. "Ueber die Thermolyse von cis- und trans-1,3-Divinylcyclobutan". . p. 990 - 993. Retrieved 2007/10/02.