7-methoxy-2-phenyl-1H-indole

Base Information

• Chemical Name: 7-methoxy-2-phenyl-1H-indole
• CAS No.: 66354-88-9
• Molecular Formula: C15H13NO
• Molecular Weight: 223.274
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID201305417
• Nikkaji Number: J1.732.911A
• Mol file: 66354-88-9.mol

Synonyms:7-methoxy-2-phenyl-1H-indole;66354-88-9;1h-indole,7-methoxy-2-phenyl-;SCHEMBL11665192;DTXSID201305417;1H-Indole, 7-methoxy-2-phenyl-;MFCD11976333;AKOS014673357;SB38196;CS-0257491;FT-0730522;EN300-6733099

Chemical Property of 7-methoxy-2-phenyl-1H-indole

Chemical Property:

• PSA: 25.02000
• LogP: 3.84350
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 223.099714038
• Heavy Atom Count: 17
• Complexity: 249

Purity/Quality:

≥95% ^*data from raw suppliers

7-Methoxy-2-phenyl-1H-indole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC2=C1NC(=C2)C3=CC=CC=C3

Technology Process of 7-methoxy-2-phenyl-1H-indole

There total 22 articles about 7-methoxy-2-phenyl-1H-indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

(E)-2-methoxy-N-(1-phenylethylidene)aniline (731797-79-8) → 7-methoxy-2-phenyl-1H-indole (66354-88-9)

Guidance literature:

With copper diacetate; palladium diacetate; In dimethyl sulfoxide; at 80 ℃; for 24h;

DOI:10.3390/molecules26134092

Reference yield: 69.0%

2-[2'-(N-Boc-N-trimethylsilyl-amino)-3'-methoxyphenyl]-1,3-dithiane (496043-85-7) → 7-methoxy-2-phenyl-1H-indole (66354-88-9)

Guidance literature:

Multistep reaction.;

DOI:10.1021/ol016924o

Reference yield: 67.0%

2-methoxy-N-(1-phenylethylidene)benzenamine (20768-48-3) → 7-methoxy-2-phenyl-1H-indole (66354-88-9)

Guidance literature:

With tetrabutylammomium bromide; oxygen; palladium diacetate; In dimethyl sulfoxide; at 60 ℃; for 24h; under 760.051 Torr;

DOI:10.1021/ja3030824

upstream raw materials:

2-methoxy-phenylamine

α-bromoacetophenone

2-[2'-(N-Boc-N-trimethylsilyl-amino)-3'-methoxyphenyl]-1,3-dithiane

3-methoxy-2-nitro-1-[(E)-2-phenylvinyl]benzene

Downstream raw materials:

2-amino-3-methoxybenzoic acid

2-(benzoyl-methyl-amino)-3-methoxy-benzoic acid

3-methoxy-2-methylamino-benzoic acid

2-benzoylamino-3-methoxy-benzoic acid

Refernces

• 1、 La Regina, Giuseppe,Bai, Ruoli,Coluccia, Antonio,Famiglini, Valeria,Pelliccia, Sveva,Passacantilli, Sara,Mazzoccoli, Carmela,Ruggieri, Vitalba,Verrico, Annalisa,Miele, Andrea,Monti, Ludovica,Nalli, Marianna,Alfonsi, Romina,Di Marcotullio, Lucia,Gulino, Alberto,Ricci, Biancamaria,Soriani, Alessandra,Santoni, Angela,Caraglia, Michele,Porto, Stefania,Da Pozzo, Eleonora,Martini, Claudia,Brancale, Andrea,Marinelli, Luciana,Novellino, Ettore,Vultaggio, Stefania,Varasi, Mario,Mercurio, Ciro,Bigogno, Chiara,Dondio, Giulio,Hamel, Ernest,Lavia, Patrizia,Silvestri, Romano. "New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer". . p. 5789 - 5807. Retrieved 2015/08/24.
• 2、 -. "PROCESSES FOR PREPARING INDOLES". Paragraph 00102. . Retrieved 2013/07/05.