20768-48-3

Upstream product

• 100-42-5 styrene 
• 90-04-0 2-methoxy-phenylamine 
• 536-74-3 phenylacetylene 
• 91-23-6 2-Nitroanisole 
• 98-86-2 acetophenone 
• 17419-98-6 N?sulfinyl?2?methoxyaniline 

Downstream Products

• 106700-04-3 2-Chloro-N-(2-methoxy-phenyl)-N-(1-phenyl-vinyl)-acetamide 
• 66354-88-9 7-methoxy-2-phenyl-1H-indole 

Relevant academic research and scientific papers

Synthesis of 2,4-diaryl-3H-1-benzazepines

Treatment of 2-fluoroaniline and some derivatives with aryl methyl ketones under acid catalysis gives the title compounds. Georg Thieme Verlag Stuttgart.

Copper-Catalyzed Cascade Cycloamination of α-Csp3-H Bond of N-Aryl Ketimines with Azides: Access to Quinoxalines

A copper-catalyzed cycloamination of α-Csp3-H bond of N-aryl ketimines with sodium azide has been developed. This methodology provides an efficient access to quinoxalines and features mild reaction conditions and readily available ketimines with diverse functional group tolerance.

Hydrogenation of nitroarenes with palladium nanoparticles stabilized by alkyne derivatives in homogeneous phase

Palladium nanoparticles stabilized by alkyne derivatives catalyzed the hydrogenation of nitroarenes to the aryl amines in homogeneous phase. The reaction of nitrobenzene proceeded smoothly with a substrate-to-palladium molar ratio (S/Pd) of 51,000 under 8 atm of H2. The reaction under 1 atm of H2 with an S/Pd of 1030 was completed in 4 h. A series of substituted nitroarenes, including 4-acetyl- and 4-formylnitrobenzenes, were converted to the aryl amines with high chemoselectivity.

Zirconium complexes stabilized by amine-bridged bis(phenolato) ligands as precatalysts for intermolecular hydroamination reactions

A series of zirconium complexes bearing amine-bridged bis(phenolato) ligands of different steric and electronic properties have been synthesized, and their activities in catalyzing intermolecular hydroamination reactions have been studied and compared. In

Pd(II)/Bu4NBr/DMSO catalytic system for practical synthesis of indoles and pyrroles from imines through aerobic dehydrogenative cyclization

N-Aryl- and N-allylimines derived typically from substituted acetophenones undergo palladium(II)-catalyzed dehydrogenative cyclization reactions in the presence of tetrabutylammonium bromide and molecular oxygen in DMSO to afford indole and pyrrole deriva

L-Pipecolinic acid derived Lewis base organocatalyst for asymmetric reduction of N-aryl imines by trichlorosilane: Effects of the side amide group on catalytic performances

A series of N-formamides derived from pipecolinic acid have been synthesized and tested as Lewis base catalysts for the enantioselective reduction of N-aryl imines by trichlorosilane. Through the investigation of the structure-efficacy relationship between the side amide group and catalytic performance, several highly effective catalysts were discovered. In particular, arylamido-type catalyst 5i and non-arylamido-type catalyst 6c exhibited high reactivity and enantioselectivity, furnishing the reduction of a wide variety of N-aryl imines with high isolated yields (up to 98%) and ee values (up to 96%) under mild conditions. Moreover, these two catalysts complement each other in terms of their tolerances to nonaromatic ketimines and non-methyl ketimines. The Royal Society of Chemistry 2013.

Oxo/imido heterometathesis between N-sulfinylamines and ketones catalyzed by a silica-supported molybdenum imido complex

Grafting the molecular complex (MesN)2Mo(CH2CMe2Ph)2 onto the surface of silica dramatically enhances its catalytic activity in the oxo/imido heterometathesis reaction of N-sulfinylamines with carbonyl compounds.

Synthesis of chiral β-amino acid derivatives by asymmetric hydrosilylation with an imidazole derived organocatalyst

The organocatalysed asymmetric hydrosilylation of a number of N-aryl and alkyl β-substituted enamino esters proceeds in generally good yield and enantioselectivity. Crucial to obtaining high yield and selectivity was the addition of benzoic acid as an additive and under these conditions, both N-alkyl and N-aryl substituents were well tolerated. β-Aryl and alkyl substituents were evaluated and a model proposed to account for the experimental observations based upon enamine tautomerisation and conformational preferences of the reactive ketimine intermediate.

Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines: Indole synthesis from anilines and ketones

We report here an operationally simple, palladium-catalyzed cyclization reaction of N-aryl imines, affording indoles via the oxidative linkage of two C-H bonds under mild conditions using molecular oxygen as the sole oxidant. The process allows quick and atom-economical assembly of indole rings from inexpensive and readily available anilines and ketones and tolerates a broad range of functional groups.

N-heterocyclic carbenes and imidazole-2-thiones as ligands for the gold(I)-catalysed hydroamination of phenylacetylene

Gold(I) complexes of 1-[1-(2,6-dimethylphenylimino)alkyl]-3-(mesityl) imidazol-2-ylidene (CImineR), 1,3-dimesitylimidazol-2-ylidene (IMes) and of the corresponding thione derivatives (SImineR and IMesS) were prepared and structurally