Propanoic acid, 2,2-dimethyl-, 3-formyl-4-nitrophenyl ester

Base Information

• Chemical Name: Propanoic acid, 2,2-dimethyl-, 3-formyl-4-nitrophenyl ester
• CAS No.: 663607-25-8
• Molecular Formula: C12H13NO5
• Molecular Weight: 251.239
• Mol file: 663607-25-8.mol

Synonyms:

Chemical Property of Propanoic acid, 2,2-dimethyl-, 3-formyl-4-nitrophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanoic acid, 2,2-dimethyl-, 3-formyl-4-nitrophenyl ester

There total 1 articles about Propanoic acid, 2,2-dimethyl-, 3-formyl-4-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.5%

2-nitro-5-hydroxybenzaldehyde (42454-06-8) + pivaloyl chloride (3282-30-2) → 2,2-dimethyl-propionic acid 3-formyl-4-nitro-phenyl ester (663607-25-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/j.bioorg.2009.04.001

Reference yield: 62.8%

2,2-dimethyl-propionic acid 3-formyl-4-nitro-phenyl ester (663607-25-8) + N-ε-tert-butoxycarbonyl-L-lysine methyl ester hydrochloride (2389-48-2) → 6-tert-butoxycarbonylamino-2-[5-(2,2-dimethyl-propionyloxy)-2-nitro-benzylamino]-hexanoic acid methyl ester (1176280-69-5)

Guidance literature:

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1016/j.bioorg.2009.04.001

Reference yield: 20.0%

3,4-diethyl-1H-pyrrole (16200-52-5) + 2,2-dimethyl-propionic acid 3-formyl-4-nitro-phenyl ester (663607-25-8) + pivaloyl chloride (3282-30-2) → 2,3,7,8,12,13,17,18-octaethylporphyrin-5,10,15,20-tetrakis(5-pivaloyloxy-2-nitrophenyl)

Guidance literature:

3,4-diethyl-1H-pyrrole; 2,2-dimethyl-propionic acid 3-formyl-4-nitro-phenyl ester; With boron trifluoride diethyl etherate; In dichloromethane; at 20 - 25 ℃; for 16h; Inert atmosphere;

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; for 3h; Inert atmosphere;

pivaloyl chloride; With N-ethyl-N,N-diisopropylamine; In chloroform; for 1h; Inert atmosphere;

DOI:10.1002/ejoc.202100154

upstream raw materials:

2-nitro-5-hydroxybenzaldehyde

pivaloyl chloride

Downstream raw materials:

6-tert-butoxycarbonylamino-2-[5-(2,2-dimethyl-propionyloxy)-2-nitro-benzylamino]-hexanoic acid methyl ester