Adenosine, 2'-deoxy-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-5'-O-[(4-methoxyphenyl) diphenylmethyl]-, 3'-[2-(4-nitrophenyl)ethyl bis(1-methylethyl)phosphoramidite]

Base Information

Chemical Name:Adenosine, 2'-deoxy-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-5'-O-[(4-methoxyphenyl) diphenylmethyl]-, 3'-[2-(4-nitrophenyl)ethyl bis(1-methylethyl)phosphoramidite]
CAS No.:663918-54-5
Molecular Formula:C59H60N7O9P
Molecular Weight:1042.14
Hs Code.:

Adenosine,
2'-deoxy-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-5'-O-[(4-methoxyphenyl)
diphenylmethyl]-, 3'-[2-(4-nitrophenyl)ethyl
bis(1-methylethyl)phosphoramidite]

Synonyms:

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Chemical Property of Adenosine, 2'-deoxy-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-5'-O-[(4-methoxyphenyl) diphenylmethyl]-, 3'-[2-(4-nitrophenyl)ethyl bis(1-methylethyl)phosphoramidite]

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Technology Process of Adenosine, 2'-deoxy-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-5'-O-[(4-methoxyphenyl) diphenylmethyl]-, 3'-[2-(4-nitrophenyl)ethyl bis(1-methylethyl)phosphoramidite]

There total 3 articles about Adenosine, 2'-deoxy-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-5'-O-[(4-methoxyphenyl) diphenylmethyl]-, 3'-[2-(4-nitrophenyl)ethyl bis(1-methylethyl)phosphoramidite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 119184-93-9
2'-deoxy-N⁶-[(9H-fluoren-9-ylmethoxy)carbonyl]-5'-O-(monomethoxytrityl)adenosine

: 153120-90-2
2-(4-nitrophenyl)ethyl diisopropylphosphoramidochloridite

: 663918-54-5
2'-deoxy-N⁶-[(9H-fluoren-9-ylmethoxy)carbonyl]-5'-O-(monomethoxytrityl)adenosine 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidite]

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1.5h;
DOI:10.1002/hlca.200390186

Reference yield:

: 87424-20-2
2'-deoxy-N⁶-[(9H-fluoren-9-ylmethoxy)carbonyl]adenosine

: 663918-54-5
2'-deoxy-N⁶-[(9H-fluoren-9-ylmethoxy)carbonyl]-5'-O-(monomethoxytrityl)adenosine 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidite]

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / pyridine / 18 h / 20 °C

2: 55 percent / EtiPr₂N / CH₂Cl₂ / 1.5 h / 20 °C

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1002/hlca.200390186

Reference yield:

: 14470-28-1
mono-4-methoxytrityl chloride

: 663918-54-5
2'-deoxy-N⁶-[(9H-fluoren-9-ylmethoxy)carbonyl]-5'-O-(monomethoxytrityl)adenosine 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidite]

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / pyridine / 18 h / 20 °C

2: 55 percent / EtiPr₂N / CH₂Cl₂ / 1.5 h / 20 °C

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1002/hlca.200390186