2-(4-nitrophenyl)ethyl diisopropylphosphoramidochloridite

Base Information

• Chemical Name: 2-(4-nitrophenyl)ethyl diisopropylphosphoramidochloridite
• CAS No.: 153120-90-2
• Molecular Formula: C₁₄H₂₂ClN₂O₃P
• Molecular Weight: 332.767
• Mol file: 153120-90-2.mol

Synonyms:2-(4-nitrophenyl)ethyl diisopropylphosphoramidochloridite

Chemical Property of 2-(4-nitrophenyl)ethyl diisopropylphosphoramidochloridite

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-nitrophenyl)ethyl diisopropylphosphoramidochloridite

There total 2 articles about 2-(4-nitrophenyl)ethyl diisopropylphosphoramidochloridite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

→ chloro-trimethyl-silane (75-77-4) + 2-(4-nitrophenyl)ethyl diisopropylphosphoramidochloridite (153120-90-2)

Guidance literature:

Reference yield:

2-(4-nitrophenyl)ethanol (100-27-6) → 2-(4-nitrophenyl)ethyl diisopropylphosphoramidochloridite (153120-90-2)

Guidance literature:

Multi-step reaction with 2 steps

1: PCl₃ / diethyl ether / 3 h / Ambient temperature

2: 1.) 0 deg C, 30 min; 2.) r.t., 20 h

With phosphorus trichloride; In diethyl ether;

DOI:10.1002/hlca.19940770123

Reference yield: 96.0%

hexadecanoic acid, 2-hydroxy-1,3-propanediyl ester (502-52-3) + 2-(4-nitrophenyl)ethyl diisopropylphosphoramidochloridite (153120-90-2) → Hexadecanoic acid 2-{diisopropylamino-[2-(4-nitro-phenyl)-ethoxy]-phosphanyloxy}-3-hexadecanoyloxy-propyl ester (177084-35-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1002/hlca.19960790210

upstream raw materials:

2-(4-nitrophenyl)ethanol

Downstream raw materials:

5'-O-(2-dansylethoxycarbonyl)-thymidine 3'-<2-(4-nitrophenyl)ethyl N,N-diisopropylphosphoramidite>

5'-O-(2-dansylethoxycarbonyl)-2'-deoxy-N⁴-<2-(4-nitrophenyl)ethoxycarbonyl>cytidine 3'-<2-(4-nitrophenyl)ethyl N,N-diisopropylphosphoramidite>

5'-O-(2-dansylethoxycarbonyl)-2'-deoxy-N⁶-<2-(4-nitrophenyl)ethoxycarbonyl>adenosine 3'-<2-(4-nitrophenyl)ethyl N,N-diisopropylphosphoramidite>

5'-O-(2-dansylethoxycarbonyl)-2'-deoxy-N²-<2-(4-nitrophenyl)ethoxycarbonyl>-O⁶-<2-(4-nitrophenyl)ethyl>guanosine 3'-<2-(4-nitrophenyl)ethyl N,N-diisopropylphosphoramidite>